| 引用本文:邵杰1，刘包欣子2，刘沈林2.中药结合西药治疗胃癌患者的临床疗效及对患者肿瘤标志物、免疫功能和生命质量的影响[J].世界中医药,2019,(04):. |
|
| 中药结合西药治疗胃癌患者的临床疗效及对患者肿瘤标志物、免疫功能和生命质量的影响 |
| Observation on the Clinical Curative Effects of Integrated Medicine in the Treatment of Gastric Cancer and Its Effects on Tumor Markers，Immunity and Life Quality |
| 投稿时间：2018-06-27 |
| DOI：10.3969/j.issn.1673-7202.2019.04.038 |
| 中文关键词: 中药 西药 胃癌 术后 疗效 肿瘤标志物 免疫功能 生命质量 |
| English Keywords:Chinese medicine Western medicine Gastric cancer Efficacy Tumor markers Immunity Quality of life |
| 基金项目:江苏省科学技术厅项目（BM2010597） |
|
| 摘要点击次数: 577 |
| 全文下载次数: 543 |
| 中文摘要: |
| 目的：探讨中药结合西药对胃癌术后患者的疗效及对其肿瘤标志物、免疫功能和生命质量的影响。方法：选取2014年12月至2017年12月江苏省中医院收治的胃癌患者64例作为研究对象，按照随机数字表法分为观察组与对照组，每组32例。对照组给予FOLFOX4方案化疗，观察组在化疗方案基础上服用中药汤剂。2组化疗均以21 d为1个周期，连续治疗6个周期。比较2组治疗疗效，治疗前后血清肿瘤标志物和免疫功能变化，生命质量各量表评分和不良反应。结果：观察组治疗有效率（75.00%）高于对照组（46.87%），差异有统计学意义（P<0.05）。2组治疗后血清癌胚抗原（CEA）、糖类抗原199（CA199）和糖类抗原125（CA125）水平降低，差异有统计学意义（观察组：t=21.662、21.964、16.706，对照组：t=8.780、13.012、9.984，P<0.05）；观察组治疗后血清CEA、CA199和CA125水平低于对照组，差异有统计学意义（t=13.992、11.731、7.302，P<0.05）。观察组治疗后CD4+和CD4+/CD8+升高而CD8+降低，差异有统计学意义（t=7.582、6.936、9.204，P<0.05）；对照组治疗后CD4+和CD4+/CD8+降低而CD8+升高，差异有统计学意义（t=5.453、5.821、11.297，P<0.05）；观察组治疗后CD4+和CD4+/CD8+高于对照组而CD8+低于对照组，差异有统计学意义（t=11.590、16.718、17.623，P<0.05）。观察组生命质量各量表评分高于对照组，差异有统计学意义（P<0.05）。观察组胃肠道反应、肝肾功能异常、血小板减少和白细胞减少发生率低于对照组，差异有统计学意义（P<0.05）。结论：中药结合西药治疗胃癌患者疗效明显，可降低血清CEA、CA199和CA125水平，增强免疫功能及改善患者生命质量。 |
| English Summary: |
| To investigate the clinical curative effects of integrated medicine in the treatment of gastric cancer patients and its effects on tumor markers，immunity and the quality of life.Methods:A total of 64 patients with gastric cancer treated in Jiangsu Province Hospital of Chinese Medicine from December 2014 to December 2017 were selected and divided into the observation group(32 cases）and the control group(32 cases）according to random number table method.The control group received FOLFOX4 chemotherapy，while the observation group were given Chinese medicine decoction in addition to the same chemotherapy.Both groups received 6 courses of treatment，and the length of each course was 21 days.The curative effects，the changes in the levels of serum tumor markers and immunity before and after the treatment，the scores of life quality and the incidence of adverse reactions were compared between the 2 groups.Results:The total effective rate of the observation group(75.00%）was higher than that of the control group(46.87%)(P<0.05).The serum CEA，CA199 and CA125 levels of the 2 groups decreased after the treatment(the observation group：t=21.662，21.964，16.706; the control group：t=8.780，13.012，9.984，P<0.05); the serum levels of CEA，CA199 and CA125 of the observation group were lower than those of the control group(t=13.992，11.731，7.302，P<0.05).After the treatment，the levels of CD4+ and CD4+/CD8+ increased，while the level of CD8+ decreased(t=7.582，6.936，9.204，P<0.05）in the observation group; in the control group，CD4+ and CD4+/CD8+ decreased while CD8+ increased(t=5.453，5.821，11.297，P<0.05）after the treatment; after the treatment，the CD4+ and CD4+/CD8+ levels of the observation group were higher than those of the control group，while the level of CD8+ was lower than that of the control group(t=11.590，16.718，17.623，P<0.05).The scores of life quality of the observation group were higher than those of the control group(P<0.05).The incidence of gastrointestinal reactions，liver and kidney dysfunction，thrombocytopenia and leukocytopenia in the observation group were lower than those in the control group(P<0.05).Conclusion:The effects of integrated medicine in the treatment of gastric cancer patients is significant.It can reduce the serum levels of CEA，CA199 and CA125，enhance immunity and improve the quality of life of the patients.It is worthy of clinical reference. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
