世界中医药

目的:本研究旨在对表现为四逆泻心汤方证的慢性胃炎患者,以四逆泻心汤颗粒进行干预,并进行临床疗效评价。方法:选取2016年7月至2017年7月北京市中西医结合医院收治的表现为四逆泻心汤方证的慢性胃炎患者60例作为研究对象,按照随机数字表法,随机分为观察组和对照组,每组30例。观察组予四逆泻心汤治疗,对照组予雷贝拉唑钠肠溶胶囊联合枸橼酸莫沙必利治疗,2组疗程均为2周。治疗后比较2组的疗效,治疗前后中医症状疗效评分、幽门螺旋杆菌(Hp)阳性情况进行评价。结果:观察组治愈4例,显效20例,有效6例,总有效率100%,对照组治愈0例,显效0例,有效17例,无效13例,总有效率56.7%,观察组总有效率高于对照组,差异有统计学意义(P<0.001);治疗2周后观察组中医症状积分明显低于对照组,差异有统计学意义(P<0.001);治疗2周后观察组中医症状改善百分比明显高于对照组,差异有统计学意义(P<0.001)。2组治疗后Hp阳性率均下降,其中观察组下降明显,差异有统计学意义(P<0.001);观察组治疗后Hp阳性率低于对照组,差异有统计学意义(P<0.05)。结论:四逆泻心汤治疗慢性胃炎,疗效显著,有广阔的应用前景。

English Summary:

To evaluate the clinical effects of Sini Xiexin Decoction on chronic gastritis with corresponding syndromes by the intervention of Sini Xiexin Decoction.Methods:Sixty patients with chronic gastritis who presented with syndromes of Sini Xiexin Decoction in Beijing Hospital of Integrated Traditional Chinese and Western Medicine from July 2016 to July 2017 were randomly divided into the observation group and the control group according to random number table，with 30 patients in each group.The observation group was treated with Sini Xiexin Decoction，while the control group was treated with Rabeprazole Sodium Enteric-coated Capsule and Mosapride Citrate for 2 weeks.After treatment，the curative effect of the 2 groups was compared，and the scores of TCM symptoms and the positive situation of Helicobacter pylori (HP) were evaluated before and after treatment.Results:In the observation group，4 patients were cured，20 patients were markedly effective，6 patients were effective，and the total effective rate was 100%.In the control group，no patient was cured，no patient was markedly effective，17 patients were effective，13 patients were ineffective，and the total effective rate was 56.7%.The total effective rate of the observation group was higher than that of the control group，and the difference was statistically significant (P<0.001); After 2 weeks of the treatment，the TCM symptom scores in the observation group were significantly lower than that of the control group，and the difference was statistically significant (P<0.001).After 2 weeks of treatment，the improvement percentage of TCM symptoms in the observation group was significantly higher than that in the control group，and the difference was statistically significant (P<0.001).After treatment，the positive rate of HP in both groups decreased，and the decrease in the observation group was significant，with statistically significant difference (P<0.001); the positive rate of HP in the observation group was lower than that in the control group (P<0.05).Conclusion:Sini Xiexin Decoction is effective in treating chronic gastritis with significant efficacy and has broad application prospects.

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