| 引用本文:张琼，侯景丽，李立军，王立军.膝关节镜术后结合活血祛瘀汤内服对膝关节炎患者骨代谢指标及炎性指标的影响[J].世界中医药,2019,(04):. |
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| 膝关节镜术后结合活血祛瘀汤内服对膝关节炎患者骨代谢指标及炎性指标的影响 |
| Effects of Knee Arthroscopic Debridement Combined with Huoxue Quyu Decoction on Bone Metabolism and Inflammatory Factors in Patients with Knee Osteoarthritis |
| 投稿时间：2018-04-04 |
| DOI：10.3969/j.issn.1673-7202.2019.04.043 |
| 中文关键词: 膝骨关节炎患者 膝关节清理术 活血祛瘀汤 骨代谢指标 炎性反应递质 膝关节镜 临床疗效 安全性 |
| English Keywords:Knee osteoarthritis Arthroscopic debridement Huoxue Quyu Decoction Inflammatory factors Knee arthroscopy Clinical efficacy Safety |
| 基金项目:抚顺市科技攻关项目(201402012) |
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| 中文摘要: |
| 目的:研究膝关节镜术后结合活血祛瘀汤内服对膝关节炎患者骨代谢指标及炎性指标的影响。方法:选取2013年6月至2016年5月抚顺市中医院骨科住院部收治的进行关节镜清理术的膝骨关节炎患者68例进行回顾性分析，按照术后治疗方法的不同分为观察组和对照组，每组34例。观察组内服活血祛瘀汤(58膝)，对照组行单纯关节镜清理术(62膝)。将2组患者术后6个月随访疗效结果进行比较。结果:6个月治疗结束后，观察组总有效率81.02%,显著高于对照组的48.55%,差异有统计学意义(P<0.05)，观察组治疗后夜间卧床休息时疼痛、晨僵或起床后疼痛加重、绞锁、肿胀以及跛行优于对照组，差异有统计学意义(P<0.05)。观察组治疗后TNF-α、IL-6改善显著，与对照组比较，差异有统计学意义(P<0.05)，观察组与对照组治疗后COMP、CTX-Ⅱ、CTX-Ⅰ、MMP-3治疗后效果显著，且观察组优于对照组，差异有统计学意义(P<0.05)。结论:活血祛瘀汤可明显降低膝关节术后患者炎性反应递质水平，患者COMP，CTX-Ⅱ，CTX-Ⅰ和MMP-3指标亦有显著改善，患者综合治疗疗效优于患者单纯使用关节镜下清理术疗效。 |
| English Summary: |
| To investigate the effects of knee arthroscopic debridement combined with Huoxue Quyu Decoction on bone metabolism and inflammatory factors in patients with knee osteoarthritis. Methods:A total of 68 patients with knee osteoarthritis undergoing arthroscopic debridement in orthopedics department of Fushun Hospital of Chinese Medicine from June 2013 to May 2016 were selected and were divided into the control group and the observation group according to their different treatment methods. There were 34 patients (62 knees) without other treatment included into control group, and 34 patients (58 knees) receiving the treatment of Huoxue Quyu Decoction included into observation group. The outcomes in 6-month follow-up period of the two groups were compared. Results:After 6 months of treatment, the total effective rate in the observation group was significantly higher than that in the control group (81.02% vs 48.55%, P<0.05); The TCM syndrome scores of the observation group such as pain during the bed rest, morning stiffness or aggravation after waking up, twisting, swelling, and claudication were better than those in the control group (P<0.05). After treatment, the TNF-α and IL-6 levels in the observation group were significantly improved, and the difference between the observation group and the control group was statistically significant (P<0.05). The levels of COMP, CTX-II, CTX-I and MMP-3 in both groups were significantly improved after treatment, and were better in the observation group than those in the control group (P<0.05). Conclusion:Compared with the arthroscopic debridement treatment alone, the arthroscopic debridement combined with Huoxue Quyu Decoction can reduce the inflammatory factors level, ameliorate the levels of COMP, CTX-II, CTX-I and MMP-3 for patients with knee osteoarthritis, which is worthy of promotion. |
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