世界中医药
文章摘要
引用本文:张昕贤1,2,陈晓农3,王朝晖3,路建饶4,胡静4,高雅婵1,2,何立群1,2.不同时间点观察肝肾同治IgA肾病的临床疗效[J].世界中医药,2019,(05):.  
不同时间点观察肝肾同治IgA肾病的临床疗效
Observing Clinical Effects of Treatment of Liver and kidney in Treatment of IgA Nephropathy at Different Time Points
投稿时间:2019-04-10  
DOI:10.3969/j.issn.1673-7202.2019.05.003
中文关键词:  肝肾同治  IgA肾病  重复测量设计  多中心  临床疗效  随机对照  中药颗粒  氯沙坦
English Keywords:Treatment of liver and kidney  IgA nephropathy  Repeated measurement design  Multi-center  Clinical Effect  Randomized control  Traditional Chinese medicine granules  Losartan
基金项目:上海市进一步加快中医药事业发展三年行动计划项目(CC-3-3003);何立群上海市名老中医学术经验研究工作室(SHGZS2017027)
作者单位
张昕贤1,2,陈晓农3,王朝晖3,路建饶4,胡静4,高雅婵1,2,何立群1,2 1 上海市名老中医何立群学术经验研究工作室,上海,200021
2 上海中医药大学附属曙光医院肾病科,上海,200021
3 上海交通大学附属瑞金医院肾病科,上海,200025
4 上海市第七人民医院肾病科,上海,200137 
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中文摘要:
      目的:多点观察通过补益肝肾中西医结合优化治疗IgA肾病的临床疗效。方法:选取2016年6月至2018年6月多中心收集IgA肾病患者80例作为研究对象,按照随机对照原则分为观察组和对照组,每组40例,观察组采用中药颗粒剂+氯沙坦的治疗方案,对照组采用中药模拟剂+氯沙坦的治疗方案,每8周测定患者24 h尿蛋白定量、尿微量白蛋白/肌酐(MA/Cr)、血肌酐(Scr)、肾小球滤过率(eGFR)并做疗效评估,共观察24周。结果:观察组总有效率为80.0%,对照组为35.0%,2组患者比较差异有统计学意义(P<0.05)。观察组24 h尿蛋白定量、MA/Cr、Scr随治疗时间延长逐渐下降,与对照组比较差异有统计学意义(P<0.05);eGFR随治疗时间延长逐渐上升,与对照组比较差异有统计学意义(P<0.05)。结论:中西医联合优化治疗方案组在降低蛋白尿、保护肾功能方面明显优于单纯西药观察组,并随时间延长优势进一步显现。
English Summary:
      To multi-point observe the clinical effect of IgA nephropathy in the optimized treatment by tonifying and replenishing liver and kidney integration traditional Chinese and western medicine.Methods:A total of 80 patients with IgA nephropathy admitted to mutil-centers from June 2016 to June 2018 were selected as subjects.According to the principle of randomized control,they were divided into an observation group and a control group,with 40 cases in each group.The observation group was treated by traditional Chinese medicine granules+Losartan,and the control group was treated by traditional Chinese medicine mimicking agent+Losartan.The 24 hours urinary protein quantitation,urinary albumin/creatinine(MA/Cr),serum creatinine(Scr)and glomerular filtration rate(eGFR)were measured every 8 weeks and perform a therapeutic evaluation,for a total of 24 weeks of observation.Results:The total effective rate was 80.0% in the observation group and 35.0% in the control group,and the difference between the 2 groups was statistically significant(P<0.05).The 24-hour urine protein quantitation,MA/Cr and Scr in the observation group were decreased gradually with extension of the treatment time,which was statistically different compared with the control group(P<0.05).eGFR in the observation group was gradually increased with the extension of treatment time,which was statistically significant compared with the control group(P<0.05).Conclusion:The integration traditional Chinese and western medicine optimized treatment group is significantly better than the western medicine alone observation group in reducing proteinuria and protecting renal function,and the advantages are further revealed with extension over time.
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