| 引用本文:杨晓萍1，黄燕莉1，王杰2，吉晶2，何立群2.肾纤维化信号通路的中医药研究进展[J].世界中医药,2019,(05):. |
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| 肾纤维化信号通路的中医药研究进展 |
| Research Progress in Traditional Chinese Medicine on Renal Fibrosis Signaling Pathway |
| 投稿时间：2019-04-10 |
| DOI：10.3969/j.issn.1673-7202.2019.05.005 |
| 中文关键词: 肾纤维化 信号通路 中医药 研究进展 |
| English Keywords:Renal fibrosis Signaling pathway Traditional Chinese medicine Research progress |
| 基金项目:浦东新区卫生系统重点专科建设资助(PWZzK2017-01);上海市名中医学术经验研究工作室(HSGZS-2017027) |
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| 中文摘要: |
| 肾纤维化可表现为肾小球硬化、肾小管-间质纤维化、肾血管硬化及肾细胞外基质(ECM)堆积,与炎性细胞浸润,促炎因子分泌异常,以及肾脏固有细胞的损伤、活化,增殖,凋亡密切相关。肾纤维化涉及包括TGFβ1-Smad、MAPK、Wnt/β-catenin、PI3K/Akt/mTOR等多条信号通路,共同的效应分子又使各通路间有串话机制,目前尚无有效的药物控制。近10年来中医药在防治肾纤维化方面积累了丰富的经验,肾纤维化信号通路研究也成为筛选和研究中药作用机制和靶点手段。 |
| English Summary: |
| Renal fibrosis can be manifested as glomerular sclerosis,renal tubulointerstitial fibrosis,renal vascular sclerosis and renal extracellular matrix(ECM)accumulation,with inflammatory cell infiltration,abnormal secretion of pro-inflammatory factors,and damage to the kidney's natural cells,activation,proliferation,and apoptosis are closely related.Renal fibrosis involves multiple signaling pathways including TGFβ1-Smad,MAPK,Wnt/β-catenin,and PI3K/Akt/mTOR,etc.The common effector molecule has a crosstalk mechanism between the pathways,and there is no effective drug to control.In the past 10 years,traditional Chinese medicine has accumulated rich experience in the prevention and treatment of renal fibrosis.The research on renal fibrosis signaling pathway has also become a mechanism and target means for screening and studying traditional Chinese medicine. |
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