世界中医药
文章摘要
引用本文:谢璇,王青,苏聪平,柳金英,张诗晗,王伟,郭淑贞.基于网络药理学的有关苓桂术甘汤干预治疗心力衰竭的作用机制〖JZ)〗〖HS)〗[J].世界中医药,2019,(05):.  
基于网络药理学的有关苓桂术甘汤干预治疗心力衰竭的作用机制〖JZ)〗〖HS)〗
Action Mechanism of Linggui Zhugan Decoction for the Treatment of Heart Failure Based on Network Pharmacology
投稿时间:2018-12-12  
DOI:10.3969/j.issn.1673-7202.2019.05.011
中文关键词:  苓桂术甘汤  网络药理学  茯苓  甘草  心力衰竭  靶点
English Keywords:Linggui Zhugan Decoction  Network pharmacology  Poria  Radix et Rhizoma Glycyrrhizae  Heart failure  Target
基金项目:国家自然科学基金项目(81874387);中央高校基本科研业务费专项资金资助项目(2018-JYBZZ-XS024)
作者单位
谢璇,王青,苏聪平,柳金英,张诗晗,王伟,郭淑贞 北京中医药大学中医学院北京100029 
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中文摘要:
      目的:根据网络药理学方法寻找苓桂术甘汤治疗心血管疾病的潜在靶点。方法:从在线的中医药生物信息学分析网站(BATMAN-TCM)筛查和预见苓桂术甘汤干预心力衰竭的可能的有效成分及其作用于心力衰竭的靶点。使用Cytoscape软件建立苓桂术甘汤以及其中所含的单味药针对心力衰竭的靶点-成分网络图。采取韦恩图(Venny 2.1)进一步研究苓桂术甘汤中茯苓及甘草治疗心力衰竭的机制。结果:我们从结果里发现苓桂术甘汤在治疗心力衰竭方面有79个活性成分,有18个靶点与心力衰竭是相关的,且检索到的靶点和有效成分有紧密的关系,找到的18个靶点主要是:ACE;ADRA2A;ADRA2B等。甘草在苓桂术甘汤中的靶点数最多,占全方治疗心力衰竭总靶点数的94.4%。结论:苓桂术甘汤改善心力衰竭的机制可能与降低AngⅡ、抑制RAS的活性、调节交感神经系统等具有相关性,其中甘草在治疗心力衰竭方面是苓桂术甘汤中最突出药物。
English Summary:
      To explore the potential targets of Linggui Zhugan Decoction for the treatment of heart failure by using network pharmacology.Methods:A bioinformatics analysis website for traditional Chinese medicine(BATMAN-TCM)was used to predict and screen the possible active components of Linggui Zhugan Decoction in the intervention of heart failure and its targets for heart failure.The Cytoscape software was used to construct a target-component network for the treatment of heart failure with Linggui Zhugan Decoction and its single medicines.Venn diagram(Venny 2.1)was used to further study the mechanism of Poria and Radix et Rhizoma Glycyrrhizae of Linggui Zhugan Decoction in the treatment of heart failure.Results:A total of 79 active components in the Linggui Zhugan Decoction were screened out from the results.There were 18 targets associated with heart failure,and the active components and targets were closely related.The 18 targets obtained mainly included:ACE; ADRA2A; ADRA2B and so on.The target number of Radix et Rhizoma Glycyrrhizae in Linggui Zhugan Decoction was the largest that it accounted for 94.4% of the total targets of the decoction in the treatment for heart failure.Conclusion:The mechanism of Linggui Zhugan Decoction in improving heart failure may be related to the decrease of AngII,the inhibition of RAS activity,and the regulation of sympathetic nervous system,etc.Among which,Radix et Rhizoma Glycyrrhizae is the most prominent in the aspect of Linggui Zhugan Decoction in treating heart failure.
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