世界中医药
文章摘要
引用本文:张历元1,李元文2,迟庆3,王玲4,肖飞4.复方紫草油体外抑菌实验研究[J].世界中医药,2019,(05):.  
复方紫草油体外抑菌实验研究
Experimental Study on Antibacterial Activity of Compound Radix Lithospermi Oil in Vitro
投稿时间:2019-03-31  
DOI:10.3969/j.issn.1673-7202.2019.05.015
中文关键词:  紫草  金黄色葡萄球菌  表皮葡萄球菌  抑菌特点  细菌培养  平板打孔法  复方紫草油  乳化剂
English Keywords:Radix Lithospermi  Staphylococcus aureus  Staphylococcus epidermidis  Bacteriostatic characteristics  Bacterial culture  Plate punching method  Compound Radix Lithospermi oil  Emulsifier
基金项目:北京中医药大学横向科研项目(HX201706)——复方紫草油治疗慢性湿疹(血虚风燥证)的临床及动物实验研究
作者单位
张历元1,李元文2,迟庆3,王玲4,肖飞4 1 北京中医药大学,北京,100027
2 北京中医药大学皮肤病研究所,北京,100027
3 大连大学医学院病原微生物实验室,大连,116622
4 健民集团儿童药物研究院,武汉,430052 
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中文摘要:
      目的:研究复方紫草油主要成分及成药的体外抑菌作用特点。方法:利用平板打孔法、牛津杯法和菌落计数法研究1)紫草、白芷、忍冬藤水煎液及不同浓度醇提液对金黄色葡萄球菌的抑制能力;2)紫草、白芷的95%乙醇浸泡液及忍冬藤水煎液对创面常见感染菌种和益生菌的抑制作用;3)含50%复方紫草油的复方紫草油-乳化剂混合物对创面常见感染菌种和益生菌的抑制作用。结果:复方紫草油的抑菌特点与紫草醇提物抑菌特点基本一致,对白色念珠菌、铜绿假单胞菌、金黄色葡萄球菌、表皮葡萄球菌等常见感染致病菌的ATCC菌株均有较好抑制作用,同时也对益生菌有一定抑制作用,对大肠埃希菌无效。结论:复方紫草油抑菌谱不等于各组分抑菌谱的简单叠加。根据该药抑菌特点,可以考虑用于烧烫伤、特应性皮炎等病的创面护理。
English Summary:
      To study the characteristics of antibacterial activity in vitro of the main components and compound medicines of compound Radix Lithospermi oil.Methods:The plate punching method,oxford cup method and colony counting method were used to study 1) the inhibitory ability of Radix Lithospermi,Radix Angelicae Dahuricae,Caulis Lonicerae Decoction and different concentrations of alcohol extract on staphylococcus aureus; 2) inhibition of common infectious strains and probiotics on wounds by 95% ethanol soaking solution of Radix Lithospermi and Radix Angelicae Dahuricae; 3) inhibition of common infectious strains and probiotics on wounds by compound Radix Lithospermi oil-emulsifier mixture containing 50% compound Radix Lithospermi oil.Results:The antibacterial characteristics of compound Radix Lithospermi oil were basically consistent with the antibacterial characteristics of licorice extract,and the ATCC strains of common pathogens such as candida albicans,pseudomonas aeruginosa,staphylococcus aureus,staphylococcus epidermidis had good inhibitory effect,but also had a certain inhibitory effect on probiotics,and was ineffective against Escherichia coli.Conclusion:The antibacterial spectrum of compound Radix Lithospermi oil is not equal to the simple superposition of the antibacterial spectrum of each component.According to the antibacterial characteristics of this medicine,wound care for burns,atopic dermatitis and other diseases can be considered..
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