世界中医药

作者	单位
张可可1，陈建新1，张芬3，段娟慧3，代耀兰4，杨若聪4，吴传鸿5，段飞鹏1，李京忠1，赵慧辉1，李韶菁1，2	1 北京中医药大学，北京，100029； 2 中国中医科学院中药研究所，北京，100700； 3 华润三九医药股份有限公司，深圳，518110； 4 西南交通大学生命科学与工程学院，成都，610031； 5 澳门大学，澳门，999078

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中文摘要:

目的：根据小儿咽扁颗粒的临床适应证，研究小儿咽扁颗粒对于急性咽炎的治疗作用，证明其疗效，并初步分析其作用环节。方法：采用咽部氨水喷雾的方法，诱发大鼠急性咽炎（Acute Pharyngitis），观察小儿咽扁颗粒对急性咽炎大鼠免疫功能、血清炎性反应因子的影响以及对咽部黏膜的保护作用。结果：连续给药7 d后，模型组与正常组比较，大鼠表观指标评分比较，差异有统计学意义（P<0.05）；小儿咽扁颗粒低剂量组可显著性降低表观指标评分。连续给药7 d后，病理学指标结果显示小儿咽扁颗粒低、中、高剂量组可不同程度改善咽部炎性反应情况。血清炎性因子检测结果显示，小儿咽扁颗粒不同剂量组可不同程度降低血清炎性因子TNF-α浓度（P<0.05；P<0.01）。结论：小儿咽扁颗粒对急性咽炎大鼠有增强免疫功能、降低血清炎性反应因子的作用，对咽部黏膜有一定保护作用。

English Summary:

To study the therapeutic effects of Xiaoer Yanbian Granules on acute pharyngitis according to its clinical indications.Methods:Acute pharyngitis in rats was induced by pharyngeal ammonia spray to observe the effects of Xiaoer Yanbian Granules on the immune function and serum inflammatory factors,and the protective effect in pharynx mucosa.Results:After 7 days of continuous administration,there was a significant difference in the apparent index score between the model group and the normal group(P<0.05).The low dose of Xiaoer Yanbian Granules significantly reduced the apparent index score.After 7 days of continuous administration,the pathological results showed that the low,medium and high doses of Xiaoer Yanbian Granules could improve the pharyngeal inflammation to different degrees.The results of serum inflammatory factor test showed that the concentration of serum inflammatory factor TNF-α was decreased to different degrees in different dosage groups of Xiaoer Yanbian Granules(P<0.05; P<0.01).Conclusion:Xiaoer Yanbian Granules could improve immune function,reduce serum inflammatory factors of rats with acute pharyngitis and protect the pharynx mucosa to some extent.

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