| 引用本文:徐乃佳，张显林.小金胶囊联合硒酵母治疗甲状腺功能正常的桥本甲状腺炎的临床观察〖JZ)〗〖HS)〗[J].世界中医药,2019,(05):. |
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| 小金胶囊联合硒酵母治疗甲状腺功能正常的桥本甲状腺炎的临床观察〖JZ)〗〖HS)〗 |
| Clinical Observation of Xiaojin Capsules Combined with Selenium Yeast in the Treatment of Hashimoto Thyroiditis with Normal Thyroid Function |
| 投稿时间：2019-03-27 |
| DOI：10.3969/j.issn.1673-7202.2019.05.029 |
| 中文关键词: 小金胶囊 硒酵母 甲状腺功能 桥本甲状腺炎 |
| English Keywords:Xiaojin Capsules Selenium teast Thyroid function Hashimoto thyroiditis |
| 基金项目:国家中药标准化项目（ZYBZH-C-HUB-20） |
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| 中文摘要: |
| 目的：观察小金胶囊（0.35 g/粒）联合硒酵母治疗甲状腺功能正常的桥本甲状腺炎的效果。方法：选取2016年6月至2018年6月武汉市中医医院收治的伴有甲状腺肿大且甲状腺功能正常的桥本甲状腺炎患者60例作为研究对象，按照随机数字表法分为观察组(n=32)和对照组(n=28)，观察组采用小金胶囊联合硒酵母治疗，对照组单纯采用硒酵母治疗，观察2组治疗前和治疗12周后中医症状评分、甲状腺各径线及最大结节长径、甲状腺功能及甲状腺过氧化物酶抗体(TPO-Ab)、甲状腺球蛋白抗体(TG-Ab)的变化。结果：治疗前2组各观察指标比较，差异均无统计学意义(P>0.05)。与治疗前比较，2组治疗后TG-Ab、TPO-Ab水平均明显降低(P<0.05)；治疗后观察组中医症状评分、甲状腺各径线明显下降(P<0.01)，对照组无明显变化(P>0.05)，2组患者甲状腺功能无明显变化、最大结节长径无明显下降(均P>0.05)，但观察组最大结节长径有下降趋势。治疗后组间比较，观察组中医症状评分明显降低(P<0.01)；TG-Ab、TPO-Ab水平、甲状腺各径线显著降低，差异均有统计学意义（均P<0.05)；观察组疗效显著优于对照组（P<0.05）；甲状腺功能、最大结节长径方面差异无统计学意义(P>0.05)。结论：对于甲状腺功能正常的桥本甲状腺炎患者，小金胶囊（0.35 g/粒）联合硒酵母治疗可以有效改善症状、缩小甲状腺及降低甲状腺自身抗体水平，有效率高；对患者的甲状腺功能没有明显影响，但结节大小有减小趋势。 |
| English Summary: |
| To observe the therapeutic effects of Xiaojin Capsules (0.35 g/capsule) combined with selenium yeast on Hashimoto thyroiditis with normal thyroid function.Methods:A total of 60 Hashimoto's thyroiditis patients with goiter and normal thyroid function admitted to Wuhan Hospital of Traditional Chinese Medicine from June 2016 to June 2018 were selected and divided into an observation group (32 cases) and a control group (28 cases) according to random number table method.The observation group was treated with Xiaojin capsule combined with selenium yeast,and the control group was treated with selenium yeast.TCM symptom scores,thyroid various diameter wire and the maximum nodal length to diameter,thyroid function and thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin (TG-Ab) of the 2 groups before treatment and 12 weeks after treatment were observed.Results:There was no significant difference between the 2 groups before treatment (P>0.05).TG-Ab and TPO-Ab levels were significantly decreased in the 2 groups after treatment than before treatment (P<0.05).In the observation group,TCM symptom score and thyroid diameter lines decreased significantly (P<0.01),while in the control group,there was no significant change (P>0.05).In the 2 groups,there was no significant change in thyroid function and no significant decrease in the maximum diameter of the nodule (P>0.05),but there was a downward trend in the maximum diameter of the nodule in the observation group.Compared with the control group,TCM symptom score of the observation group was significantly reduced (P<0.01),and TG-Ab and TPO-Ab levels and thyroid diameter lines were significantly reduced,with statistically significant differences (P<0.05).The curative efficiency of the observation group was better than the control group (P<0.05),and there was no statistically significant difference in thyroid function and maximum nodule diameter.Conclusion:For patients with normal thyroid function of Hashimoto thyroiditis,Xiaojin Capsules combined with selenium yeast treatment can effectively improve symptoms,reduce the size of thyroid and decrease the level of thyroid autoantibody,with high efficiency.Thyroid function was not significantly affected,but nodule size had a decreased tendency. |
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