To observe the therapeutic effects of Xiaojin Capsules (0.35 g/capsule) combined with selenium yeast on Hashimoto thyroiditis with normal thyroid function.Methods:A total of 60 Hashimoto's thyroiditis patients with goiter and normal thyroid function admitted to Wuhan Hospital of Traditional Chinese Medicine from June 2016 to June 2018 were selected and divided into an observation group (32 cases) and a control group (28 cases) according to random number table method.The observation group was treated with Xiaojin capsule combined with selenium yeast,and the control group was treated with selenium yeast.TCM symptom scores,thyroid various diameter wire and the maximum nodal length to diameter,thyroid function and thyroid peroxidase antibodies (TPO-Ab) and thyroglobulin (TG-Ab) of the 2 groups before treatment and 12 weeks after treatment were observed.Results:There was no significant difference between the 2 groups before treatment (P>0.05).TG-Ab and TPO-Ab levels were significantly decreased in the 2 groups after treatment than before treatment (P<0.05).In the observation group,TCM symptom score and thyroid diameter lines decreased significantly (P<0.01),while in the control group,there was no significant change (P>0.05).In the 2 groups,there was no significant change in thyroid function and no significant decrease in the maximum diameter of the nodule (P>0.05),but there was a downward trend in the maximum diameter of the nodule in the observation group.Compared with the control group,TCM symptom score of the observation group was significantly reduced (P<0.01),and TG-Ab and TPO-Ab levels and thyroid diameter lines were significantly reduced,with statistically significant differences (P<0.05).The curative efficiency of the observation group was better than the control group (P<0.05),and there was no statistically significant difference in thyroid function and maximum nodule diameter.Conclusion:For patients with normal thyroid function of Hashimoto thyroiditis,Xiaojin Capsules combined with selenium yeast treatment can effectively improve symptoms,reduce the size of thyroid and decrease the level of thyroid autoantibody,with high efficiency.Thyroid function was not significantly affected,but nodule size had a decreased tendency.