世界中医药
文章摘要
引用本文:李友山,刘凤桐,杜玉清,刘亚莉,黄天一,朱春艳.银芪软膏外治糖尿病足溃疡对创面形态及生长因子的影响〖JZ)〗〖HS)〗[J].世界中医药,2019,(05):.  
银芪软膏外治糖尿病足溃疡对创面形态及生长因子的影响〖JZ)〗〖HS)〗
Effects of Yinqi Ointment on the Wound Morphology and Growth Factors of Diabetic Foot Ulcers
投稿时间:2018-08-13  
DOI:10.3969/j.issn.1673-7202.2019.05.033
中文关键词:  银芪软膏  糖尿病足  创面愈合  生长因子  莫匹罗星软膏
English Keywords:Yinqi Ointment  Diabetic foot ulcers  Wound healing  Growth factor  Ulcer  Kangfuxin Solution
基金项目:第一届北京中医药传承“双百工程”项目;北京中医药大学东直门医院2017“青苗人才”计划(DZMYS-201701)
作者单位
李友山,刘凤桐,杜玉清,刘亚莉,黄天一,朱春艳 北京中医药大学东直门医院北京100700 
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中文摘要:
      目的:探讨银芪软膏外治糖尿病足溃疡对创面形态及生长因子的影响。方法:选取2016年12月至2017年12月东直门医院收治的糖尿病足溃疡气阴两虚证患者92例作为研究对象,随机分为观察组和对照组,每组44例,各脱落2例,在全身治疗方案及创面准备统一的基础上,观察组局部外用银芪软膏,对照组外用莫匹罗星软膏;治疗4周后,对2组患者治前、治疗后的溃疡愈合效果、溃疡面积、肉芽组织、上皮组织覆盖面积、疼痛评分及动态分析局部肉芽组织中的血管内皮生长因子(VEGF)、表皮生长因子(EGF)、碱性成纤维细胞生长因子(bFGF)等指标进行分析。结果:观察组总有效率88.37%,对照组总有效率74.42%,观察组治疗后的创面缩小率、上皮组织覆盖率、肉芽组织生长率、局部疼痛减轻率等均明显优于对照组,差异有统计学意义(P<0.05)。通过局部肉芽检测,观察组与对照组均有升高VEGF、EGF、bFGF的作用,但观察组升高生长因子作用优于对照组。结论:银芪软膏能够促进糖尿病足溃疡的愈合,其作用机制可能与提高肉芽组织中的生长因子水平有关。
English Summary:
      To discuss the effects of Yinqi Ointment on the wound morphology and growth factors of diabetic foot ulcers.Methods:A total of 92 patients with diabetic foot ulcer with TCM pattern of deficiency of both qi and yin diagnosed by Peripheral Vessel Department of Dongzhimen Hospital from December 2016 to December 2017 were randomly divided into the treatment group and the control group(44 cases with 2 drop-outs in each group)On the basis of unified systemic treatment schedule and wound surface preparation,the treatment group was treated with Yinqi Ointment and the control group was treated with Kangfuxin Solution; after 4 weeks of treatment,the healing of ulcer,ulceration area,coverage area of granulation tissue and epithelial tissue and pain scores,as well as indexes as the dynamic analysis of VEGF,EGF and bFGF in local granulation tissue of the 2 groups of patients before and after the treatment were statistically analyzed.Results:The total effective rate of the treatment group was 88.37%,and the total effective rate of the control group was 74.42%.The wound reduction rate,epithelial tissue coverage,granulation tissue growth rate and local pain reduction rate after the treatment were significantly better than that of the control group(P<0.05).Through the detection of local granulation,increased VEGF,EGF and bFGF were all detected in both the treatment group and the control group,however,the treatment group has better effect in increasing growth factors than the control group.Conclusion:Yinqi Ointment can promote the healing of diabetic foot ulcers,and its mechanism may be related to the increase of growth factor content in granulation tissue.
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