| 引用本文:朱薇，孙宝军，贾满仓.益气消癥法方药治疗冠心病的疗效及其对ERK12信号转导通路、Omentin 1的影响〖JZ)〗〖HS)〗[J].世界中医药,2019,(05):. |
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| 益气消癥法方药治疗冠心病的疗效及其对ERK12信号转导通路、Omentin 1的影响〖JZ)〗〖HS)〗 |
| Therapeutic Effects of Yiqi Xiaozheng Method on Coronary Heart Disease and Its Effects on ERK12 Signal Transduction Pathways and Omentin-1 |
| 投稿时间：2018-10-12 |
| DOI：10.3969/j.issn.1673-7202.2019.05.039 |
| 中文关键词: 冠心病 益气消癥法方药 细胞外信号调节激酶 网膜素-1 信号转导通路 |
| English Keywords:Coronary heart disease Yiqi Xiaozheng prescription ERK Omentin-1 Signal transduction pathway |
| 基金项目:河南省中医药科学研究专项课题（2014ZY02083） |
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| 中文摘要: |
| 目的：探究益气消癥法方药治疗冠心病的疗效及其对ERK12信号转导通路、Omentin-1的影响。方法：选取2017年3月至2018年3月郑州大学附属郑州中心医院收治的冠心病患者90例作为研究对象，按照随机数表法随机分为对照组和观察组，每组45例，对照组使用氯吡格雷治疗，观察组在对照组基础上联合益气消癥法方药治疗。比较2组患者的临床疗效。检测并比较2组患者治疗前后血清hs-CRP、TNF-α、和Omentin-1水平。并通过qRT-PCR反应检测MEK和ERK mRNA的表达水平。结果：观察组的有效率显著高于对照组（P<0.05）。治疗后2组心功能指标均得到显著改善（P<0.05）；治疗后观察组的LVEF显著高于对照组，LVEDD显著低于对照组（均P<0.05）。治疗后2组炎性反应因子均显著降低，治疗后观察组hs-CRP、TNF-α显著低于对照组（P<0.05）。治疗前2组MEK和ERK水平差异无统计学意义（P>0.05），治疗后均显著降低（P<0.05），治疗后观察组MEK和ERK水平均显著低于对照组（P<0.05）。术前2组Omentin-1水平差异无统计学意义（P>0.05），术后均显著升高（均P<0.05），术后观察组血清Omentin-1显著高于对照组（P<0.05）。结论：益气消癥法方药对冠心病具有更好的临床疗效，并可上调血清Omentin-1水平，提高预后；进一步的研究显示气消癥法方药可抑制MEK/ERK通路水平，降低炎性反应因子水平，可能是取得更好疗效的作用机制。 |
| English Summary: |
| To explore the therapeutic effects of Yiqi Xiaozheng method in the treatment of coronary heart disease and its effects on ERK12 signal transduction pathway and Omentin-1.Methods:A total of 90 patients with coronary heart disease treated in the Zhengzhou Central Hospital Affiliated to Zhengzhou University from March 2017 to March 2018 were selected as the study object.They were randomly divided into the control group and the observation group according to the random number table method，with 45 cases in each group.The control group was treated with clopidogrel，and the observation group was prescribed medicine of Yiqi Xiaozheng method，on the basis of the treatment of the control group.The clinical effects of the 2 groups of patients were compared.Serum hs-CRP，TNF-α，and Omentin-1 levels were detected before and after the treatment of both groups.The expression levels of MEK and ERK mRNA were detected by qRT-PCR reaction.Results:The effective rate of the observation group was significantly higher than that of the control group(P<0.05).After the treatment，the cardiac function indexes of both groups were significantly improved(P<0.05).The LVEF of the observation group was significantly higher than that of the control group after treatment，and the LVEDD was significantly lower than that of the control group(P<0.05).The inflammatory factors of the 2 groups were significantly decreased after treatment.The levels of hs-CRP and TNF-α in the observation group were significantly lower than those in the control group(P<0.05).There was no statistical significance of the difference in MEK and ERK levels between the 2 groups before treatment(P>0.05).After treatment，the levels of MEK and ERK in the observation group were significantly lower than those of the control group(P<0.05).There was no significant difference in the levels of Omentin-1 between the 2 groups before treatment(P>0.05)，while the level in both groups was significantly increased after the treatment(P<0.05).The serum Omentin-1 level of the observation group after the treatment was significantly higher than that of the control group(P<0.05).Conclusion:Yiqi Xiaozheng method has better clinical efficacy for coronary heart disease，and can up-regulate serum Omentin-1 level and improve prognosis.Further studies have shown that prescriptions of Yiqi Xiaozheng method can further inhibit the level of MEK/ERK pathways，and reduce the level of inflammatory factors，which may be related to better efficacy. |
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