| 引用本文:霍蓓蓓1，霍娜娜2，吴琳琳1.小儿金翘颗粒联合西药治疗小儿急性扁桃体炎的临床研究〖JZ)〗〖HS)〗[J].世界中医药,2019,(05):. |
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| 小儿金翘颗粒联合西药治疗小儿急性扁桃体炎的临床研究〖JZ)〗〖HS)〗 |
| Clinical Study on Xiaoer Jinqiao Granules Combined with Western Medicine in the Treatment of Acute Tonsillitis in Children |
| 投稿时间：2019-02-26 |
| DOI：10.3969/j.issn.1673-7202.2019.05.041 |
| 中文关键词: 小儿金翘颗粒 急性扁桃体炎 炎性因子 免疫功能 疗效；回顾性分析 |
| English Keywords:Xiaoer Jinqiao Granules Acute tonsillitis Inflammatory factors Immune function Curative effect Retrospective analysis |
| 基金项目:河南省高等学校专业综合改革试点项目（100401） |
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| 中文摘要: |
| 目的：探讨小儿金翘颗粒联合西药治疗小儿急性扁桃体炎的临床研究。方法:选取2016年3月至2017年9月郑州大学附属儿童医院收治的急性扁桃体炎患儿190例作为研究对象，回顾性分析其临床资料，根据治疗措施的不同分为观察组与对照组，每组95例。对照组仅给予西药治疗，观察组基于对照组联合小儿金翘颗粒治疗。2组患儿均连续治疗7 d。比较2组临床疗效；统计2组临床症状改善时间；检测并比较2组治疗前后炎性因子和T淋巴细胞亚群水平变化。结果：观察组总有效率为89.47%，显著高于对照组的77.89%（P<0.05）。观察组咽痛消失时间、退热时间及扁桃体缩小时间显著短于对照组（P<0.01）。治疗后2组患者血清IL-6、TNF-α水平相对于治疗前显著降低（P<0.01），且观察组显著低于对照组（P<0.01）。治疗后2组患儿CD4+T淋巴细胞亚群比例及CD4+/CD8+相对于治疗前显著升高，且观察组显著高于对照组（P<0.01），CD8+T淋巴细胞亚群比例相对于治疗前显著降低，且观察组显著低于对照组(P<0.01)。结论：对急性扁桃体炎患儿在常规西药治疗基础上采取小儿金翘颗粒可明显改善其临床症状，减轻其炎性反应，同时有助于其免疫功能的提高，疗效佳，值得临床应用。 |
| English Summary: |
| To explore the clinical study on Xiaoer Jinqiao Granules combined with western medicine in the treatment of acute tonsillitis in children.Methods:A total of 190 cases children of acute tonsillitis admitted in Children's Hospital Affiliated to Zhengzhou University from March 2016 to September 2017 were selected as the research objects.Their clinical data were analyzed retrospectively,and these children were divided into an observation group and a control group according to the different treatments,with 95 cases in each group.The control group was only given western medicine,while the observation group was treated with Xiaoer Jinqiao Granules based on the treatment of the control group.The 2 groups were treated continuously for 7 days.The clinical effects of the 2 groups were compared.The improvement time of clinical symptoms of the 2 groups was calculated.The levels of inflammatory factors and T-lymphocyte subsets in the 2 groups before and after the treatment were detected and compared.Results:The total effective rate of the observation group was 89.47%,which was significantly higher than 77.89% of the control group(P<0.05).In the observation group,the disappearance time of the sore throat,the antipyretic time and the time of tonsil reduction were significantly shorter than those in the control group(P<0.01).After the treatment,the levels of serum IL-6 and TNF-α in the 2 groups were significantly decreased than those before the treatment(P<0.01),and these in the observation group were significantly lower than those in the control group(P<0.01).After the treatment,the proportion of CD4+T lymphocyte subsets and CD4+/CD8+in the 2 groups were significantly increased than those before the treatment,and these in the observation group was significantly higher than those in the control group(P<0.01).The proportion of CD8+T lymphocyte subsets was significantly decreased than that before the treatment,and this in the observation group was significantly lower than that in the control group(P<0.01).Conclusion:On the basis of conventional western medicine,applying Xiaoer Jinqiao Granules can obviously improve the clinical symptoms of children with acute tonsillitis,reduce its inflammatory response,and help to improve its immune function with better curative effect,which is worthy of clinical application. |
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