| 引用本文:马丽然，江媚，刘旭昭.加减三甲复脉汤治疗肝肾阴虚绝经前后诸证的疗效及其对骨密度的影响〖JZ)〗〖HS)〗[J].世界中医药,2019,(05):. |
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| 加减三甲复脉汤治疗肝肾阴虚绝经前后诸证的疗效及其对骨密度的影响〖JZ)〗〖HS)〗 |
| Analysis of Curative Effects of Modified Sanjia Fumai Decoction on Menopausal Symptoms with Liver-Kidney Yin Deficiency and Observation of Its Effects on Bone Mineral Density |
| 投稿时间：2017-11-28 |
| DOI：10.3969/j.issn.1673-7202.2019.05.044 |
| 中文关键词: 加减三甲复脉汤 绝经前后诸证 肝肾阴虚型 骨密度 内分泌功能 替勃龙 激素替代 自主神经功能紊乱 |
| English Keywords:Modified Sanjia Fumai Decoction Menopausal symptoms Liver-kidney yin deficiency syndrome Bone mineral density Endocrine function Tibolone Hormone replacement Vegetative nerve functional disturbance |
| 基金项目:北京中医药科技发展资金项目（QN2015-02） |
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| 中文摘要: |
| 目的:观察加减三甲复脉汤治疗肝肾阴虚绝经前后诸证的疗效及对骨密度的影响。方法:选取2015年11月至2017年4月肝肾阴虚绝经前后诸证患者60例作为研究对象，按照随机数字表法随机分为对照组和观察组，每组30例。对照组给予口服替勃龙，观察组给予加减三甲复脉汤治疗。治疗6个月后，根据女性绝经期自测表(Kupperman)评分标准，统计2组临床疗效，观察2组治疗前后中医症状积分（烘热汗出、失眠、腰膝酸软、烦躁易怒、骨关节痛）、骨密度及内分泌激素水平(雌二醇E2)、促卵泡激素(FSH)及促黄体生成素(LH)的变化情况。结果:观察组治疗后总有效率为93.3%，显著高于对照组的76.8%，差异有统计学意义（P<0.05）；2组治疗后烘热汗出、失眠、腰膝酸软、烦躁易怒、骨关节痛积分均明显降低，且观察组上述中医症状积分降低更加明显，差异有统计学意义（P<0.05）；2组治疗后血清FSH、LH水平均显著降低，E2水平均显著升高，与治疗前比较，差异有统计学意义（P<0.05），2组治疗后上述内分泌激素指标水平差异无统计学意义（P>0.05）；2组治疗后骨密度T值均显著升高，差异有统计学意义（P<0.05），且观察组治疗后骨密度T值高于对照组，差异有统计学意义（P<0.05）。结论:加减三甲复脉汤能够有效改善肝肾阴虚绝经前后诸证患者临床症状，提高患者骨密度，改善自主神经系统功能紊乱的状态，疗效显著。 |
| English Summary: |
| To observe the effects of modified Sanjia Fumai Decoction in the treatment of liver-kidney yin deficiency and menopausal symptoms，as well as its effects on bone mineral density.Methods:A total of 60 patients of liver-kidney yin deficiency and menopausal symptoms were divided into the observation group and the control group according to the randomized controlled clinical trial principle，with 30 patients in each group.The control group was treated orally with tibolone，and the observation group was treated with modified Sanjia Fumai Decoction.After 6 months of treatment，the clinical efficacy of the 2 groups were observed according to the criteria of Kupperman Score，as well as TCM Symptom Score(hot flashes with sweating，insomnia，backache and weakness in legs，irritability，bone and joint pain)，bone mineral density and changes of endocrine hormone levels ［Estradiol(E2)，Follicle-Stimulating Hormone(FSH）and Luteinizing Hormone(LH)］ of the two groups before and after the treatment.Results:The total effective rate of the observation group after treatment was 93.3%，which was significantly higher than that of the control group，and the difference between groups was statistically significant(P<0.05).The TCM Symptom Score of hot flashes with sweating，insomnia，backache and weakness in legs，irritability，bone and joint pain of both group were significantly lowered after the treatment，and that of the observation group was more obvious，whose difference was statistically significant(P<0.05).The serum FSH and LH levels of both group were significantly decreased after treatment，while the E2 levels were significantly increased.The difference in hormone levels before and after treatment was statistically significant(P<0.05)，while there was no significant difference in the above endocrine hormone levels between the 2 groups(P>0.05).The bone mineral density T values of both group were significantly increased after treatment(P<0.05)，and the increase of the observation group was significantly higher than that of the control group; the difference between the two groups was statistically significant(P<0.05).Conclusion:The modified Sanjia Fumai Decoction can effectively improve the vegetative nerve functional disturbance of patients with liver-kidney yin deficiency and menopausal symptoms，increase bone mineral density and significantly improve the clinical symptoms of patients. |
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