| 引用本文:杨夏，李焕平.白芍总苷治疗系统性红斑狼疮患者的临床疗效及对免疫功能的影响〖JZ)〗〖HS)〗[J].世界中医药,2019,(05):. |
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| 白芍总苷治疗系统性红斑狼疮患者的临床疗效及对免疫功能的影响〖JZ)〗〖HS)〗 |
| Clinical Efficacy of Total Glucosides of Paeony on Systemic Lupus Erythematosus and its Effects on Immune Function |
| 投稿时间：2018-10-29 |
| DOI：10.3969/j.issn.1673-7202.2019.05.045 |
| 中文关键词: 白芍总苷 系统性红斑狼疮 疗效 免疫功能；症状积分；活动指数 |
| English Keywords:Total glucosides of paeony Systemic lupus erythematosu Efficacy Immune function Symptom score Activity index |
| 基金项目:医学研究基金项目（2016-10） |
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| 中文摘要: |
| 目的：探讨白芍总苷（TGP）治疗系统性红斑狼疮（SLE）患者的临床疗效及对免疫功能的影响。方法：选取2015年3月至2018年5月内蒙古包钢医院收治的SLE患者106例作为研究对象，按照随机数字表法分为对照组和观察组，每组53例。对照组采用常规治疗方法，观察组在对照组基础上增加白芍总苷（TGP）治疗，2组均连续治疗3个月。比较2组患者治疗后临床疗效、中医症状改善情况及治疗前后SLE疾病活动度指数（SLEDAI）评分、免疫功能，记录治疗期间不良反应发生情况。结果：治疗后观察组总有效率为94.34%，明显高于对照组的79.25%，差异有统计学意义（P<0.05）。与治疗前比较，治疗后2组患者中医症状积分均明显降低，差异有统计学意义（P<0.05），且观察组明显低于对照组，差异有统计学意义（P<0.05）。治疗后2组患者SLEDAI评分均明显低于治疗前，差异有统计学意义（P<0.05），且观察组明显低于对照组，差异有统计学意义（P<0.05）。与治疗前比较，治疗后对照组患者全血中CD4+比例及观察组CD4+比例和CD4+/CD8+均明显升高，差异有统计学意义（P<0.05），且观察组明显高于对照组（P<0.05）。2组总不良反应发生率差异无统计学意义（P>0.05）。结论：在常规治疗基础上加用TGP治疗SLE可明显改善患者中医症状，降低疾病活动度，改善患者免疫功能，提高治疗效果，且并未增加不良反应的发生。 |
| English Summary: |
| To investigate the clinical efficacy of total glucosides of paeony (TGP) on systemic lupus erythematosus (SLE) and its effects on immune function.Methods:A total of 106 patients with SLE in Inner Mongolia Baotou Steel Hospital from March 2015 to May 2018 were divided into an observation group and a control group according to the random number table method,with 53 cases in each group.The control group received conventional treatment,and the observation group added TGP treatment on the basis of the control group.The clinical efficacy,improvement of traditional Chinese medicine (TCM) symptoms after treatment,the scores of SLE disease activity index (SLEDAI) and immune function were compared between the 2 groups after 3 months continuous treatment,and the adverse reactions during the treatment were recorded.Results:After treatment,the total efficiency rate of the observation group was 94.34%,which was significantly higher than 79.25% of the control group (P<0.05).Compared before treatment,the scores of various TCM symptoms significantly decreased after treatment (P<0.05),and the observation group was significantly lower than the control group (P<0.05).The score of SLEDAI significantly decreased after treatment compared with before in the 2 groups (P<0.05),and the observation group was significantly lower than the control group (P<0.01).Compared with before treatment,the ratio of CD4+ in the whole blood of the patients in the control group and the ratio of CD4+ and CD4+/CD8+ in the observation group significantly increased (P<0.05),and the observation group was significantly higher than the control group (P<0.05).There was no significant difference in the incidence of total adverse reactions between the 2 groups (P>0.05).Conclusion:The treatment of SLE with application of TGP based on conventional treatment can significantly improve TCM symptoms,reduce disease activity,improve immune function of patients,enhance treatment efficacy.And there is no increase of the incidence of adverse reactions. |
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