| 引用本文:林茂，张德利，刁庆春.毫火针联合补肾活血方对寻常型进展期白癜风的疗效及对血清可溶性细胞间黏附分子 1水平的影响〖JZ)〗〖HS)〗[J].世界中医药,2019,(05):. |
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| 毫火针联合补肾活血方对寻常型进展期白癜风的疗效及对血清可溶性细胞间黏附分子 1水平的影响〖JZ)〗〖HS)〗 |
| Effects of Milled Fire Needle Combined with Bushen Huoxue Recipe in the Treatment of Common Type Vitiligo Patients in Advanced Stage and its Effects on Serum Sicam-1 Level |
| 投稿时间：2019-01-10 |
| DOI：10.3969/j.issn.1673-7202.2019.05.054 |
| 中文关键词: 白癜风 进展期 毫火针 补肾活血方 可溶性细胞间黏附分子-1 疗效 |
| English Keywords:Vitiligo Advanced stage Milled fire needle Bushen Huoxue Recipe Soluble intercellular adhesion molecule-1 Curative effects |
| 基金项目:重庆市科研院所绩效激励引导专项项目(cstc2018jxjl0073) |
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| 中文摘要: |
| 目的：毫火针联合补肾活血方对寻常型进展期白癜风的疗效及对血清可溶性细胞间黏附分子-1（sICAM-1）水平的影响。方法：选取2016年7月至2017年12月重庆市中医院收治的寻常型进展期白癜风患者95例作为研究对象，随机分为对照组（n=47）和观察组（n=48），2组均在常规治疗的基础上给予补肾活血方，观察组在此基础上应用毫火针治疗，1个疗程为4周，均连续治疗3个疗程。统计2组临床疗效；比较2组治疗前后白癜风病变面积改善情况；检测并比较治疗前后2组血清sICAM-1、干扰素-γ（IFN-γ）、粒细胞-巨噬细胞集落刺激因子（GM-CSF）、Treg细胞比例；记录治疗期间2组不良反应发生情况。结果：对照组和观察组起效时间分别为（25.46±10.36）d、（18.59±9.63）d，观察组较对照组明显缩短，差异有统计学意义（P<0.05）；治疗后2组白癜风皮损面积均较治疗前减小，且观察组改善效果优于对照组（P<0.01）。观察组临床总有效率为95.83%显著高于对照组的70.21%，差异有统计学意义（P<0.05）。与治疗前比较，治疗后2组血清sICAM-1、IFN-γ含量降低，且观察组低于对照组，差异有统计学意义（P<0.05）。与治疗前比较，治疗后2组CD4+CD25+Treg细胞比例升高，GM-CSF含量降低，且观察组CD4+CD25+Treg细胞比例高于对照组，GM-CSF含量低于对照组，差异有统计学意义（P<0.05）。2组不良反应发生率差异无统计学意义（25.00%比12.50%，P>0.05）。结论：毫火针联合补肾活血方治疗寻常型进展期白癜风疗效显著，可降低血清sICAM-1、IFN-γ等炎性反应递质的表达，调节患者免疫功能，延缓疾病的进展，且安全性较好。 |
| English Summary: |
| To study the effects of milled fire needle combined with Bushen Huoxue recipe in the treatment of common type vitiligo patients in advanced stage and its effects on serum soluble intercellular adhesion molecule-1 (sICAM-1) level.Methods:A total of 95 cases of patients with common type vitiligo in advanced stage admitted to Chongqing Traditional Chinese Medicine Hospital from July 2016 to December 2017 were randomly divided into a control group (n=47) and an observation group (n=48).The 2 groups were given Bushen Huoxue Recipe on the basis of routine treatment,and the observation group was treated with milled fire needle on this basis.The 1 course of treatment was 4 weeks,and all had 3 courses treatment continuously.The clinical effect of the 2 groups were statistically analyzed,and the improvement of the skin lesion area of vitiligo before and after treatment in the 2 groups were compared,and the levels of serum sICAM-1,IFN-γ,GM-CSF and Treg cells ratio before and after treatment were compared.Adverse reactions of the 2 groups were recorded during the treatment period.Results:The onset time of control group and observation group were (25.46±10.36) d,(18.59±9.63) d respectively,and observation group was significantly shorter than the control group (P<0.01).After treatment,the area of vitiligo skin lesions in both groups decreased,and the improvement effect of observation group was better than that of control group (P<0.01).The total effective rate of the observation group was significantly higher than that of the control group (95.83% vs 70.21%,P<0.01).Compared with before treatment,the levels of serum sICAM-1 and IFN-γ in the 2 groups decreased after treatment,and the observation group was lower than the control group (P<0.01).The proportion of CD4+ CD25+Treg cells in the 2 groups increased and the content of GM-CSF decreased compared with before treatment (P<0.01),and the proportion of CD4+ CD25+Treg cells in the observation group was higher than that of the control group,and the content of GM-CSF was lower than that of the control group (P<0.01).There was no significant difference in the incidence of adverse reactions between the 2 groups (25.00% vs 12.50%,P>0.05).Conclusion:Milled fire needle combined with Bushen Huoxue recipe is effective in the treatment of common type vitiligo patients in advanced stage.It can reduce the expression of serum inflammatory cytokines such as sICAM-1 and IFN-γ,modulate the immune function of the patients and postpone the progress of the disease,and the safety is better. |
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