| 引用本文:刘芳，陶思攸，曾惠芬，缪蕙，沈明静.针刀松解术对类风湿关节炎肘关节僵硬患者炎性反应递质和氧自由基的影响〖JZ)〗〖HS)〗[J].世界中医药,2019,(05):. |
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| 针刀松解术对类风湿关节炎肘关节僵硬患者炎性反应递质和氧自由基的影响〖JZ)〗〖HS)〗 |
| Effects of Acupotomy Loosing Treatment on Inflammatory Factors and Oxygen Free Radicals in Rheumatoid Arthritis Patients with Elbow Joint Stiffness |
| 投稿时间：2019-01-10 |
| DOI：10.3969/j.issn.1673-7202.2019.05.055 |
| 中文关键词: 类风湿关节炎 肘关节僵硬 炎性反应递质 氧自由基 类风湿因子 针刀松解术 |
| English Keywords:Rheumatoid arthritis Elbow joint stiffness Inflammatory factors Oxygen free radicals Rheumatoid factor Acupotomy loosing treatment |
| 基金项目:深圳市龙岗区2016年度医疗卫生科技项目(20160606162550856） |
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| 中文摘要: |
| 目的：探讨针刀松解术对类风湿关节炎（RA）肘关节僵硬患者炎性反应递质和氧自由基的影响。方法：选取2016年2月至2018年3月龙岗中心医院收治的RA肘关节僵硬患者72例作为研究对象，按照抽签法随机分为对照组和观察组，每组36例。对照组采用西医常规治疗联合针刺，观察组采用西医常规治疗联合针刀松解术。比较2组患者的炎性反应递质、氧自由基代谢水平、红细胞沉降率、类风湿因子及肘关节活动范围等指标。结果：治疗后，2组患者的血清白细胞介素-6（IL-6）、肿瘤坏死因子-ɑ（TNF-α）、丙二醛（MDA）、红细胞沉降率（ESR）和类风湿因子（RF）水平均降低，超氧化物歧化酶（SOD）水平均升高，且观察组较对照组显著，差异有统计学意义（P<0.05）；2组患者的肘关节延伸最大角度降低，屈曲最大角度和活动范围增加，且观察组患者的肘关节活动功能的改善较对照组明显，差异有统计学意义（P<0.05）。结论：针刀松解术联合常规西医治疗能有效抑制RA肘关节僵硬患者体内的炎性反应和氧自由基反应，下调RF水平，促进患者关节功能恢复，临床效果更优。 |
| English Summary: |
| To explore the effects of acupotomy loosing treatment on inflammatory factors and oxygen free radicals in rheumatoid arthritis (RA) patients with elbow joint stiffness.Methods:A total of 72 RA patients with elbow join stiffness treated in Longgang Central Hospital from February 2016 to March 2018 were randomly divided into an observation group and a control group according to envelope method,with 36 patients in each group.The control group received conventional western medicine combined with acupuncture,and the observation group received conventional western medicine combined with acupotomy loosing treatment.The inflammatory factors,oxygen free radicals,blood sedimentation,rheumatoid factors and range of elbow joint were compared between the 2 groups.Results:After treatment,the serum levels of IL-6,TNF-α,MDA,ESR and RF all declined,while the levels of SOD rose in the 2 groups,and the changes in the observation group were more significant than those in the control group,with statistical significance (P<0.05).The maximum angle of elbow extension decreased,the maximum angle of flexion and the range of motion increased in the 2 groups,and the improvement of elbow function in the observation group was more significant than that in the control group (P<0.05).Conclusion:Compared with acupuncture,acupotomy loosing treatment combined with conventional western medicine can effectively suppress inflammation and oxygen free radical reaction,reduce the level of RF,and promote the recovery of joint function in RA patients with elbow join stiffness,with better clinical efficacy. |
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