To select the dominant frequency of electroacupuncture(EA)in treating chronic inflammatory pain，to observe the effects of different frequency EA on DRG p-TRPV1 of rats with chronic inflammatory pain，and to explore the mechanism of DRG p-TRPV1 activation by dominant frequency EA.Methods:All rats were randomly divided into a control group，a model group，a 2 Hz EA group，a 100 Hz EA group and a 2/100 Hz EA group.Except for the control group，rats of other groups were given CFA hypodermic injection into the plantar surface of the right hind paw of SD rats.In the EA group，Zusanli(ST36)and Kunlun(BL60)acupoints on both sides were selected，05 mA-15 mA，30 mins per time.Von Frey Hair was used to detect the PWT and PWL in the affected side of rats at different time points，and western blot was used to detect the expression of DRG p-TRPV1 in rats.Results:100 Hz EA can effectively improve the PWT of CFA rats(P<005)，and 100 Hz and 2/100 Hz EA can increase the PWL of CFA rats(P<005，P<005); the expression of L4-6 DRG p-TRPV1 protein in CFA model rats was up-regulated，and there is no significant difference in L4 level(P>005)，otherwise L5 and L6 levels were up-regulated significantly(P<005)100 Hz EA can effectively inhibit the overexpression of L5 DRG p-TRPV1 protein in CFA rats(P<005).While the overexpression of L4 and L6 DRG p-TRPV1 protein decreased，but there was no significant difference(P>005).Conclusion:100 Hz EA has the best analgesic effect on chronic inflammatory pain，which may be related to its effective down-regulation of L5 DRG p-TRPV1 protein expression in CFA rats.