To select the optimal alcohol precipitation of Kangzhi suppository by orthogonal test.Methods:The alcohol precipitation was optimized by orthogonal test using alcohol concentration，relative density and standing time as factors，with Berberine Hydrochloride and paste-forming rate as examining indexes.Results:The optimal conditions were as follows，alcohol concentration was 60%，relative density was 110-120 and standing time was 24 h.Conclusion:The optimized alcohol precipitation process of kangzhi suppository by orthogonal test determined that the productive technology was reasonable，scientific and feasible.