To study the effects of modified Yinchenhao Decoction combined with budesonide on airway responsiveness and expression of inflammatory cytokines in lung tissue of asthmatic mice.Methods:Male SD rats were divided into a control group，a model group and a treatment group.After making asthma model，the mice were treated with modified Yinchenhao Decoction combined with budesonide.The airway resistance，the number of inflammatory cells in bronchoalveolar lavage fluid(BALF)and the expression of inflammatory cytokines in lung tissue were measured.Results:The airway resistance，the number of neutrophils，eosinophils and lymphocytes in BALF and the expression of interleukin-2(IL-2)，IL-6，interferon-γ(IFN-γ)，eotaxin，CCL19 and CCL21 in lung tissue of model group mice were significantly higher than those of control group(P<005).The airway resistance after MCh injection and the number of neutrophils，eosinophils and lymphocytes in BALF and the expression of IL-2，IL-6，IFN-γ，eotaxin，CCL19 and CCL21 in lung tissue of treatment group were significantly lower than those of the model group(P<005).Conclusion:Modified Yinchenhao Decoction combined with budesonide can reduce airway reactivity and inhibit inflammation in lung tissue of asthmatic mice，which shows positive value in the treatment of asthma.