To explore the medication rules of traditional Chinese medicine (TCM) compound prescription of diabetes mellitus (DM) based on data mining technology.Methods:Taking the Chinese prescription database as the retrieval database,the traditional Chinese medicine (TCM) prescription for treating “消渴”,“脾瘅”,“消瘅”,“消渴病”,“肺消”,“膈消”,“消中” and “肾消” was searched to establish prescription database of TCM compound prescription in the treatment of DM,and Excel,SPSS 22 software was used for frequency analysis,factor analysis,cluster analysis etc.,and then the quantitative and qualitative analysis of the regularity of TCM compound medication was conducted and its possible mechanism was discussed.Results:TCM compound prescription of DM involves 605 prescriptions,426 kinds of Chinese medicine,93 flavors of high frequency herbs.Radix Glycyrrhizae,Radix Ophiopogonis,Radix Ginseng,Poria,Radix Trichosanthis,Rhizoma Coptidis are commonly used; Qi-tonifying herbs,heat-clearing and fire-purging herbs,heat-clearing and dampness-drying herbs,yin-tonifying herbs are most commonly used; Cold,neutral,light cold,warm,and light warm of four properties of drugs; Sweet,bitter,pungent and slightly bitter of five flavors; Lung,spleen,heart,stomach and kidney channels of channel tropism were most commonly chosen; Totally 10 common factors were extracted from the factor analysis,and the cumulative contribution rate was 3333%,among them,tonifying deficiency mainly relied on invigorating qi and yin,replenishing blood and promoting body fluid,and purging excess mainly relied on clearing heat and fire,clearing heat and drying dampness,inducing diuresis for removing edema,clearing heat and cooling blood,etc.,and the main treatment principles was strengthening the vital qi and eliminating pathogenic factors; totally 10 drug groups were obtained by cluster analysis.Conclusion:Clinical treatment of DM is mostly from the lung,spleen and stomach,heart and kidney,and reinforcing the vital qi and eliminate the pathogenic factors is the main treatment principle.Nourishing yin and tonifying blood,invigorating qi and invigorating spleen combined with clearing heat and purging fire,clearing heat and drying dampness,promoting qi and activating blood circulation and other methods were mostly used for selecting the corresponding TCM prescription to treat the disease.