Chronic heart failure is a common and complex disease.More and more studies have found that “deficiency,toxicity and stasis” constitute the pathogenesis of chronic heart failure.Based on this,Prof.Wang Wei created the “Qishen Granules”,taking the functions of nourishing qi and warming yang,promoting blood circulation,clearing heat and detoxification,and improving heart function and attenuating ventricular remodeling.Based on the 3 elements of “deficiency,toxicity and stasis”,this paper described their roles in the pathogenesis of heart failure,and elaborated on the formula basis and basic research results of Qishen Granules,which may provide ideas and references for the treatment of chronic heart failure.