To explore the clinical effects of Wang Boyue modified Malian Decoction in treating children with acute glomerulonephritis based on syndrome differentiation，and to analyze the possible mechanism of curative effect，so as to provide a reference for the choice of treatment programs for children with acute glomerulonephritis.Methods:A total of 60 children with acute glomerulonephritis admitted to Shenzhen Baoan Hospital of Traditional Chinese Medicine from April 2015 to April 2017 were selected as the study subjects.The patients were numbered according to the order of treatment.The odd number was the control group(30 cases)and the even number was the observation group(30 cases).The control group was treated with routine western medicine，anti-infection，diuresis，antihypertensive routine symptomatic treatment，and the observation group was treated with Wang Boyue modified Malian Decoction favored prescription on the basis of symptomatic treatment drugs halved.Two groups of children were treated for 2 weeks for a course of treatment.The changes of renal function index(24 h urinary protein，serum creatinine(Scr)，urinary protein(BUN)，serum inflammatory index(anti-streptococcal hemolysin O，interleukin-6(IL-6)，interleukin-10(IL-10)，erythrocyte sedimentation rate(ESR)，immune function index(CD3+，CD4+，CD8+，CD4+/CD8+)were compared between the 2 groups before and after treatment.After treatment，the clinical efficacy was evaluated and compared，and adverse drug reactions were collected and compared.Results:1)The total effective rate of clinical diseases in the study group was significantly higher than that in the control group(P<005).2)After treatment，24-hour urinary protein，Scr，BUN in both groups were significantly decreased than those before treatment，and the observation group was significantly lower than the control group(P<005).3)After treatment，the levels of anti-streptolysin O and IL-10 in the 2 groups were significantly decreased than those before treatment，and the levels of IL-6 and ESR in the observation group were significantly increased than those in the control group(P<005).4)After treatment，the CD3+，CD4+，CD8+，CD4+/CD8+ ratio of the 2 groups were significantly increased than before treatment，and the observation group was higher than the control group(P<005).5)The adverse drug reaction rate of the control group was significantly higher than that of the observation group(P<005).Conclusion:The modified prescription of Wang Boyue Malian Decoction has the effects of dispersing lung，diuresis，clearing away heat and detoxification，thus enhancing the antibacterial ability，renal function and immune function of children，and improving the clinical efficacy of children with acute glomerulonephritis.The dosage of antibiotics is reduced，the safety is high，and the clinical value is high.