To explore the clinical value of Yixinshu capsule combined with Bisoprolol fumarate in the treatment of hypertrophic cardiomyopathy on patients with clinical symptoms/signs.Methods:From January 2013 to December 2017，160 patients with hypertrophic cardiomyopathy and clinical symptoms/signs(qi-blood obstruction syndrome)were enrolled in Luhe Hospital of Beijing for clinical observation.All the patients were divided into 2 groups according to the order of visiting，the control group(80 cases)and the observation group(80 cases).The control group was treated with BIS，and the observation group was treated with BIS+Yixinshu capsule.The course of treatment was 1 month.The changes of left ventricular end-diastolic pressure，left ventricular outflow tract pressure gradient and NYHA cardiac function grading，the improvement of patients' conscious symptoms and quality of life，and the overall clinical efficacy(total effective rate)before and after treatment were investigated.Results:1)After treatment，the total effective rates of the 2 groups were 9643% and 7857%，respectively.The observation group had a higher total effective rate(χ2=3840，P=0045).2)After treatment，left ventricular end-diastolic pressure，left ventricular outflow tract pressure gradient and cardiac function grading in both groups were significantly improved compared with those before treatment(P<005).The improvement of left ventricular end-diastolic pressure(t=9048，P=0000)，left ventricular outflow tract pressure gradient(t=3345，P=0001)and cardiac function classification(t=4637，P=0000)in the observation group were more significant than those in the control group.3)After treatment，the 2 groups of patients had significant improvement compared with before treatment(P<005).There were significant differences in conscious symptoms(t=24199，P=0000)and quality of life(t=8627，P=0000)between the 2 groups.4)Heart rate slowed down in 2 cases(225%，2/80)in the observation group and 9 cases(1011%，9/80)in the control group.There was a significant difference in the incidence of adverse reactions between the 2 groups(χ2=7320，P=0007).Conclusion:Yixinshu capsule combined with BIS combined with traditional Chinese and Western medicine can achieve better clinical effects in patients with hypertrophic cardiomyopathy.The improvement of patients' conscious symptoms and quality of life is more significant，and the improvement of cardiac function index is better.