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引用本文:张彬，莫伟明，阮勇.复方苦参注射液结合FOLFOX4方案治疗结直肠癌的相关指标变化分析[J].世界中医药,2019,(06):.

复方苦参注射液结合FOLFOX4方案治疗结直肠癌的相关指标变化分析

Analysis of the Changes of Related Indexes of Compound Sophora Flavescens Injection Combined with FOLFOX4 Regimen for the Treatment of Colorectal Cancer

投稿时间：2018-09-18

DOI：10.3969/j.issn.1673-7202.2019.06.027

中文关键词: 复方苦森注射液 FOLFOX4方案结直肠癌晚期免疫系统 NK 胃肠激素中西结合

English Keywords:Compound Sophora flavescens injection FOLFOX4 regimen Colorectal cancer Advanced stage Immune system NK Gastrointestinal hormone Combination of Chinese and western medicine

基金项目:湖北卫生厅资助项目（12502333）

作者	单位
张彬，莫伟明，阮勇	湖北省黄石市第二医院普外科，黄石，435000

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中文摘要:

目的：分析复方苦参注射液结合FOLFOX4方案对结直肠癌相关指标的变化。方法：选取2017年1月至2017年12月黄石市第二医院收治的结直肠癌且确诊为晚期的患者119例作为研究对象进行回顾性分析。以不同的治疗方式分为观察组（n=58）和对照组（n=61），观察组患者术后采取复方苦参注射液结合FOLFOX4方案辅助治疗；对照组患者术后采取FOLFOX4方案辅助治疗。分析2组相关指标的变化。2组均治疗4个疗程。结果：1）4个疗程后，观察组IgA（174±035）mg/mL、IgG（1019±153）mg/mL、IgM（194±047）mg/mL，对照组IgA（126±022）mg/mL、IgG（807±065）mg/mL、IgM（143±030）mg/mL。2组比较差异有统计学意义（P<005）。2）观察组治疗后CD3+（5254±681）%、CD4+（3236±535）%、CD8+（3088±316）%、CD4+/CD8+（119±037）、NK（1285±384）%；对照组治疗后CD3+（6214±521）%、CD4+（4528±445）%、CD8+（2212±279）%、CD4+/CD8+（167±048）、NK（1865±349）%。治疗后2组间各指标比较，差异均有统计学意义（P<005）。3）4个疗程后观察组MOT（40236±5835）ng/L、SS（21519±4077）pg/L、NO（5894±527）μmol/L；对照组MOT（64928±7145）ng/L、SS（17967±3728）pg/L与NO（4581±602）μmol/L。2组治疗后各指标比较，差异有统计学意义（P<005）。4）中医证候积分：观察组经过治疗总分从（1212±043）降至（354±038），对照组经过治疗总分从（1207±040）降至（618±039）。2组治疗后中医证候积分比较，差异有统计学意义（P<005）。5）癌症治疗效果：观察组总有效率9310%，明显高于对照组的7869%，2组比较差异有统计学意义（P<005）。结论：复方苦参注射液结合FOLFOX4方案治疗结直肠癌效果显著，适用于生存期较短的晚期结直肠癌患者。

English Summary:

To study the changes of related indexes of compound Sophora flavescens injection combined with FOLFOX4 regimen for the treatment of colorectal cancer.Methods:From January 2017 to December 2017，119 patients with advanced colorectal cancer admitted to the Second Hospital of Huangshi were selected and analyzed retrospectively.According to different treatment methods，the patients were randomly divided into an observation group and a control group58 patients in the observation group were treated with compound Sophora flavescens injection combined with FOLFOX4 regimen after operation，while 61 patients in the control group were treated with FOLFOX4 regimen.The significance of the change of relative indexes between groups was analyzed.Results:1)Immunoglobulin detection:after 4 courses of treatment，in the observation group，IgA(174±035)mg/mL，IgG(1019±153)mg/mL，IgM(194±047)mg/mL; in the control group，IgA(126±022)mg/mL，IgG(807±065)mg/mL，IgM(143±030)mg/mL.2)Detection of T lymphocytes and NK cells:after treatment in the observation group，CD3+(5254±681)%，CD4+(3236±535)%，CD8+(3088±316)%，CD4+/CD8+(119±037)and NK(1285±384)%; In the control group，CD3+(6214±521)%，CD4+(4528±445)%，CD8+(2212±279)%，CD4+/CD8+(167±048)and NK(1865±349)%.3)Gastroenterohormone related indexes:in the observation group after 4 courses of treatment，MOT(40236±5835)ng/L，SS(21519±4077)pg/L and NO(5894±527)umol/L; In the control group，MOT(64928±7145)ng/L，SS(17967±3728)pg/L and NO(4581±602)umol/L.4)Syndromes of TCM:in the observation group，the total score were improved from(1212±043)to(354±038); in the control group，the total score were improved from(1207±040)to(618±039).5)The treatment effect:in 58 patients of the observation group，4 cases were PD(69%)，in 61 patients of the control group，13 cases were PD(2131%).Conclusion:The compound Sophora flavescens injection combined with FOLFOX4 regimen is effective in the treatment of colorectal cancer.It is suitable for patients with advanced colorectal cancer with shorter survival period.

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