To explore the effects of Salvia Rhizoma Miltiorrhiza and Rhizoma Chuanxiong combined with bone melon or Ossotide on glucose metabolism and bone metabolism in patients with diabetic osteoporosis.Methods:From March 2016 to September 2017，253 diabetic patients with osteoporosis treated in The Second Hospital of Huangshi were selected as the study object.The bone melon group included 128 cases treated with Rhizoma Salviae Miltiorrhizae and Rhizoma Chuanxiong，combined with bone melon.The ossotide group included 125 cases treated with Rhizoma Salviae Miltiorrhizae and Rhizoma Chuanxiong，combined with ossotide.The fluctuation of bone metabolism，glucose metabolism and other related biochemical indexes were analyzed before and after treatment.The drug safety was also compared.Results:1）After the treatment，there was no significant difference in glucose metabolism(HbA1c(741±064)%，Ca(221±028）mmol/L，FBG(612±059）mmol/L，P(142±025）mmol/L，HbA1c(779±051）%，Ca(227±033）mmol/L，FBG(637±083）mmol/L，P(135±031）mmol/L）between the bone melon group and the ossotide group(P>005);2）There was no significant difference in N-MID-OT(1637±283）ng/mL between the ossotide group and the bone melon group(P>005)，while BAP(14226±1066）μg/L，BGP(507±132）μg/L of the ossotide group were significantly lower than that of the bone melon group，and BMP-2(8635±624）ng/L significantly higher than that of the bone melon group(P<005);3）The BMD(057±013）g/cm3 of the ossotide group was significantly higher than that of the bone melon group，while PTH(3226±215）pg/mL，ALP(7235±519）U/L were significantly lower than that of the bone melon group(P<005); there was no significant difference in β-CTx between the ossotide group(039±002）ng/mL and the bone melon group(042±004）ng/mL(P>005).4）The adverse reaction rate of the bone melon group(313%）was lower than that of the ossotide group(960%)(P<005).Conclusion:For the treatment based on Rhizoma Salviae Miltiorrhizae and Rhizoma Chuanxiong on patients with diabetic osteoporosis，compared to bone melon，the ossotide injection can improve multiple indexes of bone metabolism，serum biochemical indexes and BMD.Both have similar effects in regulating glucose metabolism，but the side effects of ossotide are relatively higher，so it is preferred to select drugs according to individual conditions.