| 引用本文:黄宗志，陈超，卓书喜，邓行行.筋骨活血汤治疗骨折急性疼痛患者的疗效及对炎性反应递质水平的影响[J].世界中医药,2019,(06):. |
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| 筋骨活血汤治疗骨折急性疼痛患者的疗效及对炎性反应递质水平的影响 |
| Efficacy of Jingu Huoxue Decoction on Acute Pain of Fracture and its Effects on the Levels of Inflammatory Factors |
| 投稿时间：2018-12-21 |
| DOI：10.3969/j.issn.1673-7202.2019.06.035 |
| 中文关键词: 筋骨活血汤 骨折 疼痛 疗效 炎性反应递质 致痛因子 |
| English Keywords:Jingu Huoxue Decoction Fracture Pain Efficacy Inflammatory factors Pain-causing factors |
| 基金项目:2017年度市科技计划医疗类项目（2017-13） |
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| 中文摘要: |
| 目的：探讨筋骨活血汤治疗骨折急性疼痛患者的疗效及对炎性反应递质水平的影响。方法：选取2015年4月至2018年5月琼海市中医院收治的骨折急性疼痛患者128例作为研究对象，按随机数字表法分为观察组和对照组，每组64例。入院后2组患者均进行相应的外科手术治疗，术后对照组采用布洛芬治疗，观察组采用筋骨活血汤治疗，2组均连续治疗4周。比较2组患者治疗后临床疗效，治疗前后中医症状改善情况，致痛因子水平，炎性反应递质水平及休息时、活动时、按压时疼痛程度。结果：治疗后观察组总有效率为9375%，明显高于对照组的8125%，差异有统计学意义（P<005）。与治疗前比较，治疗后2组患者肿胀、红肿、疼痛、活动障碍评分均明显降低，且观察组明显低于对照组，差异有统计学意义（P<005）。与治疗前比较，治疗后2组患者休息时、活动时及按压时视觉模拟评分法（VAS）评分均明显降低，且观察组明显低于对照组，差异有统计学意义（P<005）。与治疗前比较，治疗后2组患者血浆前列腺素E2（PGE2）、缓激肽（BME）及血清白细胞介素-6（IL-6）、白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）水平均明显降低，且观察组明显低于对照组，差异有统计学意义（P<005）。结论：筋骨活血汤可降低骨折急性疼痛患者炎性反应递质水平，减轻肿胀、红肿等症状，缓解疼痛，改善骨折部位活动障碍，临床疗效优于布洛芬。 |
| English Summary: |
| To investigate the efficacy of Jingu Huoxue Decoction on acute pain of fracture and its effects on the levels of inflammatory factors.Methods:A total of 128 cases of patients with acute pain of fracture in Qionghai Hospital of Traditional Chinese Medicine from April 2015 to May 2018 were selected and divided into an observation group and a control group according to the random number table method,with 64 cases in each group.After admission,the 2 groups of patients were treated with corresponding surgical treatment.The control group was treated with ibuprofen after operation,and the observation group was treated with Jingu Huoxue Decoction.The 2 groups were treated continuously for 4 weeks.The clinical efficacy,the improvement of traditional Chinese medicine (TCM) symptoms,the levels of pain-causing factors and inflammatory factors,the degree of pain at rest,activity and compression were compared before and after treatment between the 2 groups.Results:After treatment,the total efficiency of the observation group was 9375%,which was significantly higher than 8125% of the control group (P<005).Compared with before treatment,the scores of swelling,redness,pain and activity disorder significantly decreased after treatment in the 2 groups (P<001),and the observation group was significantly lower than the control group (P<005 or P<001).Compared with before treatment,the VAS at rest,activity and compression significantly decreased after treatment in the 2 groups (P<001),and the observation group was significantly lower than the control group (P<001).Compared with before treatment,the levels of PGE2,BME in plasma and IL-6,IL-1β and TNF-α in serum significantly decreased after treatment in the 2 groups (P<001),and the observation group was significantly lower than the control group (P<005 or P<001).Conclusion:Jingu Huoxue Decoction can decrease the levels of inflammatory factors in patients with acute pain of fracture,reduce the swelling and redness symptoms,relieve pain,improve the movement dysmotility of fracture site,and the clinical efficacy is better than ibuprofen. |
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