Abstract:To investigate the efficacy of Jingu Huoxue Decoction on acute pain of fracture and its effects on the levels of inflammatory factors.Methods:A total of 128 cases of patients with acute pain of fracture in Qionghai Hospital of Traditional Chinese Medicine from April 2015 to May 2018 were selected and divided into an observation group and a control group according to the random number table method,with 64 cases in each group.After admission,the 2 groups of patients were treated with corresponding surgical treatment.The control group was treated with ibuprofen after operation,and the observation group was treated with Jingu Huoxue Decoction.The 2 groups were treated continuously for 4 weeks.The clinical efficacy,the improvement of traditional Chinese medicine (TCM) symptoms,the levels of pain-causing factors and inflammatory factors,the degree of pain at rest,activity and compression were compared before and after treatment between the 2 groups.Results:After treatment,the total efficiency of the observation group was 9375%,which was significantly higher than 8125% of the control group (P<005).Compared with before treatment,the scores of swelling,redness,pain and activity disorder significantly decreased after treatment in the 2 groups (P<001),and the observation group was significantly lower than the control group (P<005 or P<001).Compared with before treatment,the VAS at rest,activity and compression significantly decreased after treatment in the 2 groups (P<001),and the observation group was significantly lower than the control group (P<001).Compared with before treatment,the levels of PGE2,BME in plasma and IL-6,IL-1β and TNF-α in serum significantly decreased after treatment in the 2 groups (P<001),and the observation group was significantly lower than the control group (P<005 or P<001).Conclusion:Jingu Huoxue Decoction can decrease the levels of inflammatory factors in patients with acute pain of fracture,reduce the swelling and redness symptoms,relieve pain,improve the movement dysmotility of fracture site,and the clinical efficacy is better than ibuprofen.