To observe the clinical efficacy of Kekeling Mixture combined with Reduning Injection in the treatment of viral pneumonia in children and its effects on immune functions.Methods:A total of 68 children with viral pneumonia in Zhangjiagang Hospital of TCM from June 2017 to September 2018 were randomly divided into an observation group and a control group according to the random number table，with 34 cases in each group.The observation group was given Kekeling Mixture and Reduning Injection，and the control group was given ambroxol hydrochloride oral solution and ribavirin injection.The changes of fever，cough，expectoration，wheezing，lung auscultation and X-ray chest anterior film were observed before and after treatment.And changes in peripheral blood IL-6 and T lymphocyte subsets in children before and after treatment were also observed.Results:After treatment，fever，cough，expectoration，wheezing，lung auscultation and chest X-ray were better than before treatment.Moreover，the improvement of wheezing symptom in the observation group was more obvious than the control group after treatment，and the total score after treatment in the observation group was significantly lower than that of the control group(P>005).The levels of IL-6 and CD8+ in the 2 groups were decreased than those before treatment，and CD3+，CD4+ and CD4+/CD8+ were increased than those before treatment.The increase of CD3+ and CD4+/CD8+ in the observation group was more obvious than that in the control group.The observation group reduced CD8+ more obviously，and the difference was statistically significant(P<005).The difference of the curative effect between the observation group and the control group was statistically significant(P<005).Conclusion:Kekeling Mixture combined with Reduning Injection is effective in the treatment of children with viral pneumonia and heat-blocking lung syndrome.It can significantly improve the symptoms and signs of children，and can effectively correct the immune dysfunction in children.It is safe and worthy of clinical promotion and application.