| 引用本文:朱伟1，倪伟2.至灵菌丝胶囊对阴阳两虚型高血压的疗效观察及部分机制探析[J].世界中医药,2019,(06):. |
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| 至灵菌丝胶囊对阴阳两虚型高血压的疗效观察及部分机制探析 |
| Curative Effect Observation of Cordyceps Capsules on Yin and Yang Deficiency Hypertension and Part of the Mechanism Analysis |
| 投稿时间：2018-12-29 |
| DOI：10.3969/j.issn.1673-7202.2019.06.039 |
| 中文关键词: 高血压 阴阳两虚型 至灵菌丝胶囊 MAU Lp-PLA2 |
| English Keywords:Hypertension Type of both yin and yang deficiency Cordyceps Capsules MAU Lp-PLA2 |
| 基金项目:上海市科技发展基金项目(01-4319404);上海浦东新区卫生行业科研专项(PW2016E-3) |
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| 中文摘要: |
| 目的:观察至灵菌丝胶囊对阴阳两虚型高血压的疗效,并对其作用机制进行探析。方法:选取2017年5月至2018年5月上海市金山区中西医结合医院收治的阴阳两虚型高血压患者90例作为研究对象,随机分为对照组与观察组,每组45例。2组患者均接受高血压饮食指导,并予口服降压药进行血压调控,观察组在上述治疗基础上加用至灵菌丝胶囊,以28 d为1个疗程,2组患者均治疗1个疗程,疗程结束后比较2组患者中医证候积分变化、24 h动态血压、微量白蛋白尿(MAU)以及Lp-PLA2变化。结果:1)治疗后2组患者中医证候积分均较前有所下降,差异有统计学意义(P<005),观察组疗效更优。2)治疗后2组患者收缩压(SBP)和舒张压(DBP)均见明显下降(P<005),其中观察组SBP降压效果显著优于对照组(P<005)。3)治疗后观察组MAU水平为(2838±976)mg/L,与对照组(4726±1626)mg/L,差异有统计学意义(P<005)。2组患者治疗后MAU均明显低于治疗前,差异均有统计学意义(P<005)。4)2组患者治疗后Lp-PLA2浓度均有明显下调,与治疗前比较差异有统计学意义(P<005),其中观察组下调的趋势更为明显。结论:至灵菌丝胶囊可明显改善阴阳两虚型高血压的病情,其作用机制可能与下调Lp-PLA2浓度有关。 |
| English Summary: |
| To observe the curative effects of Cordyceps Capsules on both yin and yang deficiency type hypertension，and to analyze the mechanism of action.Methods:A total of 90 cases of patients with both yin and yang deficiency type hypertension in Shanghai Jinshan District Hospital of Integrated Traditional Chinese and Western Medicine were included into the study，and randomly divided into a control group and an observation group，with 45 cases in each group.Both of the 2 groups accepted hypertension dietary guidance and oral antihypertensive agents in blood pressure regulation.The observation group combined with Cordyceps Capsules based on the above treatment.Both groups had 28 days for a course of treatment.Both of the two groups had 2 courses of treatment.After treatment，the TCM syndrome integrals changes，and the changes of 24 h ambulatory blood pressure，microalbuminuria(MAU)and Lp-PLA2 of the 2 groups were compared.Results:1)TCM syndrome integrals declined in the 2 groups of patients after treatment than before，with statistically significant differences(P<005).The curative effect of the observation group was better.2)Systolic blood pressure(SBP)and diastolic blood pressure(DBP)were obviously decreased in the 2 groups after treatment(P<005)，and the antihypertensive effect on SBP in the observation group was significantly better than that of the control group(P<005).3)After treatment，MAU levels of the observation group were(2838±976)mg/L，and that of the control group were(4726±1626)mg/L，the differences were statistically significant(P<005).MAU of the 2 groups after treatment were significantly lower than before treatment，and the differences were statistically significant(P<005).4)The Lp-PLA2 concentrations were significantly decreased in the 2 groups after treatment，and the differences were statistically significant compared with before treatment(P<005).The downward trend of the observation group was more obvious.Conclusion:Cordyceps Capsules can significantly improve the state of both yin and yang deficiency type hypertension，and the mechanism may associated with the down-regulation of Lp-PLA2 concentration. |
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