| 引用本文:王冰，姜华.益气化痰方辅助治疗对晚期非小细胞肺癌患者化疗敏感性的影响及作用机制[J].世界中医药,2019,(06):. |
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| 益气化痰方辅助治疗对晚期非小细胞肺癌患者化疗敏感性的影响及作用机制 |
| Effects of Yiqi Huatan Decoction Adjuvant Therapy on Chemosensitivity in Advanced Non-small Cell Lung Cancer Patients and its Mechanism |
| 投稿时间：2018-09-16 |
| DOI：10.3969/j.issn.1673-7202.2019.06.040 |
| 中文关键词: 晚期非小细胞肺癌 益气化痰方 化疗敏感性 耐药基因 肿瘤绝对体积 肿瘤标志物 血管新生标志物 顺铂 |
| English Keywords:Advanced non-small cell lung cancer Yiqi Huatan Decoction Chemosensitivity Drug-resistant gene Absolute volume of tumors Tumor markers Angiogenesis markers Cisplatin |
| 基金项目:辽宁省科技厅项目(2016235018) |
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| 中文摘要: |
| 目的：探讨益气化痰方辅助治疗对晚期非小细胞肺癌（NSCLC）患者化疗敏感性的影响及作用机制。方法：选取2012年8月至2017年9月本溪市中心医院收治的晚期NSCLC患者80例作为研究对象，按照随机数表法分为对照组和观察组，每组40例。对照组接受常规化疗，观察组接受益气化痰方辅助常规化疗。比较2组患者治疗前后肿瘤绝对体积、肿瘤标志物及血管新生标志物水平、病灶活检组织中耐药基因表达的差异。结果：治疗前，2组肿瘤绝对体积、肿瘤标志物及血管新生标志物水平、病灶活检组织中耐药基因表达差异无统计学意义（P>005）。治疗2疗程后，观察组患者肺部原发病灶肿瘤绝对体积小于对照组；血清中肿瘤标志物鳞状细胞癌相关抗原（SCC-Ag）、细胞角蛋白19片段（CYFRA21-1）、糖类抗原125（CA125）的水平低于对照组；血清中血管新生标志物基质金属蛋白酶-2（MMP-2）、血管内皮生长因子（VEGF）、血小板反应蛋白-1（TSP-1）、内皮素-1（ET-1）的水平低于对照组，TSP-1的水平高于对照组；病灶组织中耐药基因MRP、MDR1、LRP mRNA的表达低于对照组（P<005）。结论：晚期NSCLC患者在化疗同时加入益气化痰方辅助治疗，可进一步提升患者的化疗敏感性，具体与该药物抑制耐药基因表达直接相关。 |
| English Summary: |
| To study the effects of Yiqi Huatan Decoction adjuvant therapy on chemosensitivity in advanced non-small cell lung cancer(NSCLC)patients and its mechanism.Methods:A total of 80 cases of advanced NSCLC patients in Benxi City Center Hospital during August 2012 to September 2017 were divided into a control group(n=40)underwent conventional chemotherapy and an observation group(n=40)underwent Yiqi Huatan Decoction adjuvant therapy combined with conventional chemotherapy according to the random number table.The difference of tumor absolute volume，contents of tumor markers and neovascularization markers，and the expression of resistance genes in the biopsy tissues of the 2 groups were compared before and after treatment.Results:Before treatment，there were no significant difference between the 2 groups in total volume of tumor，contents of tumor markers and neovascularization markers，expression of resistance genes in the biopsy tissue between the 2 groups(P>005)2 courses after treatment，the absolute volume of primary lung tumor in the observation group was less than that in control group; serum contents of tumor markers such as SCC-Ag，CYFRA21-1 and CA125 were lower than those in the control group; serum contents of neovascularization markers such as MMP-2，VEGF and ET-1 in the observation group were lower than those in the control group，and TSP-1 was higher than that in the control group; the expression of resistance genes such as MRP，MDR1，LRP mRNA in the observation group were lower than those in the control group(P<005).Conclusion:Yiqi Huatan Decoction adjuvant therapy for advanced NSCLC patients bases on chemotherapy，can further enhance the sensitivity of chemotherapy，which is directly related to the drug resistance gene expression. |
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