To investigate the application and safety analysis of Leonurus injection combined with Gedan in hemorrhage of placenta previa cesarean section.Methods:A total of 64 pregnant women with placenta previa admitted into Chongqing Red Cross Hospital from December 2015 to August 2017 were selected and randomly divided into a control group (n=32) and an observation group (n=32).All the patients were treated with correction of anaemiat and lumbar-epidural anesthesia before surgery.The control group was given ocytocin instillation,while the observation group was given Leonurus injection combined with Gedan instillation.The amount of blood loss,laboratory indicators,adverse reactions,prognosis and efficacy were observed and compared between the 2 groups.Results:The explicit efficiency was 9063% in the observation group and 7111% in the control group,with statistical significance between the 2 groups (P<005).The amount of intraoperative blood loss,2 h postoperative blood loss,24 h postoperative blood loss and intraoperative blood transfusion in the observation group were all less than those in the control group (P<005).The levels of 24 h postoperative Hb and RBC in the observation group were higher than those in the control group (P<005).There was no significant difference in the 24 h postoperative coagulation function indexes (PT and TT) between the 2 groups (P>005).The incidence of complications in the observation group was significantly lower than that in the control group (P<005),and the rate of uterine involution was significantly higher than that in the control group (P<005).There was no significant difference in the incidence of adverse reactions between the 2 groups (P>005).Conclusion:On the basis of the use of oxytocin,Leonurus injection combined with Gedan has significant hemostatic effects,significantly reduce the incidence of complications,promote uterine involution with high efficacy and safety without affecting the body's coagulation system in hemorrhage of placenta previa cesarean section.