To explore the effects of Fuzheng Xiaoliu decoction with CIK cells on the clinical improvement in the treatment of patients with advanced malignant tumor.Methods:A total of 82 cases patients with advanced malignant tumor in Hainan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine from January 2016 to June 2017 were selected and randomly divided into a control group and an observation group,with 41 cases in each group.The control group was treated with CIK cells adoptive immunotherapy,and the observation group was treated with Fuzheng Xiaoliu Decoction on the basis of the control group.One month after treatment,the recent clinical curative effect of 2 groups was statisticsed,and the TCM symptoms integral changes of the 2 groups were evaluated.The changes of immune index levels of 2 groups were compared,and the occurrence of adverse reactions of the 2 groups during the treatment was observed.Results:The total remission rate of the observation group was 6098%,which was significantly higher than 3415% of the control group (P<005); Compared with before treatment,the TCM symptoms integral of the observation group after treatment significantly declined,and the observation group was significantly lower than control group (P<005 or P<001); Compared with before treatment,the ratio of NK cells,T lymphocytes of CD3+,CD4+ and the ratio of CD4+/CD8+ significantly increased,and the observation group was significantly higher than the control group (P<005 or P<001).The CD8+ T lymphocytes levels of the 2 groups significantly reduced,and the observation group was significantly lower than the control group (P<005).The total incidence of adverse reactions in the observation group was 1707%,and the total incidence of adverse reactions in the control group was 1951%.There was no significant difference between the 2 groups (P>005).Conclusion:Fuzheng Xiaoliu Decoction with CIK cells can significantly improve the immune function of patients with advanced malignant tumors,reduce the clinical symptoms.The effect is significant,and it is safe and reliable.