Objection:To investigate the effects of Pinggan Ditan Tongluo Decoction combined with acupuncture of unblocking the brain and quickening the collaterals on acute cerebral infarction(ACI)and neurological function.Methods:A total of 115 patients with ACI admitted in the department of brain in our hospital from February 2017 to June 2018 were randomly divided into a decoction group and a combination group,including 58 cases in the decoction group and 57 cases in the combination group.On the basis of conventional western medicine treatment,the decoction group was treated with Pinggan Ditan Tongluo Decoction,and the combination group was treated with Pinggan Ditan Tongluo Decoction combined with acupuncture of unblocking the brain and quickening the collaterals.Indicators like effective rate,neurological function,plaque area,carotid intima-media thickness(IMT)and endothelial function of the 2 groups were observed and compared.Results:After the treatment,the total effective rate was 9483% in the combination group and 8246% in the decoction group.The difference between the 2 groups was statistically significant(P<005).After 2-week and 4-week treatment,the National Institutes of Health Stroke Scale(NIHSS)score,brain natriuretic peptide precursor N-terminal peptide(NT-proBNP),S-100β,plaque area,and IMT were lower than those before the treatment(P<005).The improvement of the above indexes in the combination group was significantly higher than that in the acupuncture group,with statistically significant difference(P<005).After 2 and 4 weeks of treatment,the levels of endothelin(ET)in the 2 groups were lower than that before the treatment.The levels of nitric oxide(NO)and calcitonin gene-related peptide(CGRP)were higher than those before the treatment(P<005),and the ET level of the combination group was significantly lower than that of the acupuncture group,while the NO and CGRP levels were significantly higher than those of the acupuncture group.The difference was statistically significant(P<005).Conclusion:On the basis of conventional western medicine treatment,Pinggan Ditan Tongluo Decoction combined with acupuncture of unblocking the brain and quickening the collaterals on ACI can effectively improve neurological deficits,better inhibit arterial plaque formation,reduce IMT and protect vascular endothelial function.It is more conducive to the prognosis of patients.