Zhizichi Decoction is the main formula for the treatment of annoyance in the heart,vexation,fever and insomnia in the Treatise on Cold-induced and Miscellaneous Diseases.Later generations expand and apply it to treat diverse diseases and its curative effect is quite good.“Formula-pattern element correspondence” is developed on the basis of the theory of “correspondence between formula and pattern” and is used to explore the relationship between the pattern elements and the formula elements.It is a basic mode of thinking which belongs to formula construction in clinical practice and emphasizes the logical relationship between “theory,method,formula and medicine” at the same time,so that the target of medicinal combination is more clear.In order to expand the application of Zhizichi Decoction and its derived formulas in clinical practice as well as expanding the thinking of medication,the theory of “formula-pattern element correspondence” was used to analyze the Zhizichi Decoction and its derived formulas,and explore its evolutionary rule.