To retrospectively analyze the rule of prescription of traditional Chinese medicine(TCM)in chronic renal failure(CRF)with 6 years follow-up treated by Professor Yi Wuyong based on data mining technique.Methods:From January 2012 to August 2018，the prescriptions of traditional Chinese medicine and the data of outpatient cases were collected from the outpatient department of Professor Yi Wuyong for 6 years，and the data of one dimension and two dimensions were analyzed by Python.The FP-growth algorithm was used to get the frequency of the first 1 000 multidimensional data analysis; Gephi software was used to visualize the network diagram，the law and characteristics of drug use were summarized.Results:In the prescription，267 kinds of Chinese medicine pieces were used.The most frequently used Chinese medicine was Radix Astragali seu Hedysari(970%)，the structure analysis showed that the property of warm medicine(410%)and the cold medicine(360%)were the most frequently used.In the flavor aspect，sweet medicine(324%)and bitter medicine(302%)were used most frequently.In the channel tropism，the medicine into the liver channel(194%)was the most frequently used.The drugs of tonifying deficiency(509%)were the most frequently used，followed by blood activating drugs(177%).The highest three dimensional and four dimensional analysis combinations were Radix Astragali seu Hedysari，Cortex Moutan Radicis，fried Fructus Aurantii Immaturus; Radix Astragali seu Hedysari，Cortex Moutan Radicis，fried Fructus Aurantii Immaturus，Radix et Rhizoma Rhei; Astragali seu Hedysari，Cortex Moutan Radicis，fried Fructus Aurantii Immaturus，Radix et Rhizoma Rhei，Radix Rehmanniae Preparata.Conclusion:Professor Yi Wuyong's treatment of chronic renal failure is mainly in accordance with the combination of cold and warm，adjustment of sweet and bitter，tonifying qi and strengthening healthy qi，invigorating the kidney and promoting blood circulation，soothing the liver and regulating qi，dredging viscera and removing turbidity，invigorating spleen and removing dampness，which matches the theory of traditional Chinese medicine treatment.It can provide a reference for the treatment of chronic renal failure.