世界中医药
文章摘要
鼻渊通窍颗粒联合克拉霉素治疗小儿慢性鼻窦炎的临床疗效及对炎性反应因子的影响
Clinical Effects of Biyuan Tongqiao Granule Combined with Clarithromycin in Children with Chronic Sinusitis and Its Influence on Inflammatory Factors
投稿时间:2019-02-26  
DOI:10.3969/j.issn.1673-7202.2019.07.033
中文关键词: 慢性鼻窦炎  鼻渊通窍颗粒  克拉霉素  鼻黏膜纤毛输送率  炎性反应因子
英文关键词: Chronic sinusitis  Biyuan Tongqiao Granule  Clarithromycin  Nasal mucociliary transport rate  Inflammatory factors
基金项目:河南省中医药科学研究专项项目(2016zy2064)
作者单位
陈旎珺1,吴继昌1,胡原1,柳普照2 1 上海交通大学医学院附属瑞金医院耳鼻咽喉科,上海,200025
2 河南中医药大学第一附属医院耳鼻喉科,郑州,450000 
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中文摘要:
      目的:探究鼻渊通窍颗粒联合克拉霉素治疗小儿慢性鼻窦炎的临床疗效及对炎性反应因子的影响。方法:选取2016年7月至2018年5月上海交通大学医学院附属瑞金医院收治的慢性鼻窦炎患儿121例作为研究对象,按照随机数字表法分为对照组(n=61)和观察组(n=60),对照组采用克拉霉素治疗,观察组在对照组基础上加用鼻渊通窍颗粒。比较2组患者治疗效果评分、炎性反应因子水平、鼻黏膜纤毛输送率(MTR)、鼻黏膜纤毛清除率(MCC)和有效率。结果:观察组有效率为91.67%,显著高于对照组的70.00%(P<0.05)。治疗后,2组患者视觉模拟评分(VAS)评分、内镜黏膜形态评分、鼻窦CT扫描病变评分、IL-2和IL-6水平均降低(P<0.05),且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,2组患者MTR和MCC水平均升高(P<0.05),且观察组高于对照组(P<0.05)。结论:鼻渊通窍颗粒联合克拉霉素治疗小儿慢性鼻窦炎,降低炎性反应水平,增强鼻黏膜纤毛功能,能够改善临床症状。
英文摘要:
      To explore the clinical effects of Biyuan Tongqiao Granule combined with clarithromycin in children with chronic sinusitis and its influence on inflammatory factors.Methods:A total of 121 children with chronic sinusitis treated in Ruijin Hospital Affiliated to Medical College of Shanghai Jiaotong University from July 2016 to May 2018 were divided into an observation group(n=60)and a control group(n=61)according to random number table.The control group was treated with clarithromycin,while the observation group was additionally treated with Biyuan Tongqiao Granule on this basis.The scores of therapeutic effect,the levels of inflammatory factors,nasal mucociliary transport rate(MTR),nasal mucociliary clearance rate(MCC)and effective rate were compared between the 2 groups.Results:The effective rate in the observation group was 91.67%,which was significantly higher than 70.00% in the control group(P<0.05).After treatment,the scores of visual analogue scale(VAS),endoscopic mucosal morphology,sinus CT scan lesion,the levels of IL-2 and IL-6 in the 2 groups all decreased(P<0.05),and the observation group was lower than those in the control group,with statistical differences(P<0.05).After treatment,the levels of MTR and MCC in both groups increased(P<0.05),and the observation group was higher than those in the control group(P<0.05).Conclusion:Biyuan Tongqiao Granule combined with clarithromycin can improve the clinical symptoms of chronic sinusitis in children by reducing the level of inflammation and enhancing the ciliary function of nasal mucosa.
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