Cancer-ralated fatigue(CRF)of breast cancer is common in breast cancer and can occur in all stages of breast cancer treatment.Whether the effective intervention of CRF can be operated has become an important guarantee for breast cancer patients to maintain the smooth progress of postoperative chemotherapy.Space-time acupuncture is a new acupuncture method summarized by Professor Zhu Miansheng on the basis of an ancient method of acupoint selection in line with time and the absorption of European medical culture.According to Professor Zhu Miansheng's long-term clinical experience and preliminary clinical observation，the space-time acupuncture of eight methods of sacred tortoise(SAEMST)for breast cancer CRF intervention has strong clinical operability and a good application prospect，and the curative effect is relatively positive，which can effectively improve the fatigue and other symptoms caused by the tumor itself or tumor treatment，and improve the quality of life of patients.This project aims to explore the effectiveness，safety and feasibility of the SAEMST for the intervention of breast cancer CRF through a strict experimental design.Methods:A total of 40 patients adopting early-stage chemotherapy after breast cancer operation in Yunnan Cancer Hospital from March 2018 to May 2019 were selected as research objects，and they were randomly divided into 3 groups：SAEMST group，acupuncture of non-meridian and non-acupoint(ANN)group，and blank control group(simple adjuvant chemotherapy treatment).According to the ratio of 2:1:1，there were 20 cases in the SAEMST group，10 cases in the ANN group，and 10 cases in the blank control group.The 3 groups of patients were enrolled and underwent relevant operations.During the whole process of adjuvant chemotherapy，except the blank control group，the other 2 groups received acupuncture treatment once a week.Scale assessments and peripheral blood tests were performed at 4 time points.T1：baseline; T2：after 4 cycles of epirubicin+cyclophosphamide(EC); T3：after 4 cycles of taxol; and T4：the end of 1 month after the chemotherapy.At present，all the patients in this project are out of the groups.This paper evaluates the experimental program of SAEMST from aspects of feasibility，safety and effectiveness of the experiment，so as to provide experience and evidence for the further clinical trial in the next step.Conclusion:This program has strong operability，with good patient compliance，as well as safe and effective clinical operation.This acupuncture program runs through the diagnosis methods of inspection，listening and smelling，inquiring and pulse-taking and palpation，the concept of “ syndrome differentiation and treatment”，the treatment principles of “depending on time，place and person” and “treatment aming at its root causes” in traditional Chinese medicine(TCM)，and realizes the organic combination of TCM individualized treatment with the requirements of clinical trial standardization，which is repeatable in clinical trials and treatment.