To observe the effects of Xuefu Zhuyu Decoction on vascular remodeling and cardiomyocyte apoptosis in coronary heart disease model rats.Methods:A total of 30 SD rats were randomly divided into sham operation group，model group and intervention group，with 10 rats in each group.Rats in the model group and intervention group were fed with high-fat diet for 7 weeks to prepare coronary heart disease model.Rats in the intervention group received Xuefu Zhuyu Decoction by gavage.Rats in the model group and the sham operation group received the same dose of normal saline by gavage for 4 weeks.After the intervention，cardiac function and coronary blood flow were measured in each group of rats，and the coronary artery and left ventricular tissue were taken after the rats were killed.Pathological changes of the coronary artery and left ventricular tissue were observed by HE staining.Expressions of PI3K，AKT，Bcl-2 and Bax were detected by Western blotting.Results: 1)Compared with the sham operation group，the absolute values of LVSP,-dp/dtmax and+dp/dtmax in the model group were decreased obviously，with statistical significance(P<005)，in which the above indexes in the intervention group were up-regulated compared with those in the model group. 2)The left ventricular myocardium in the model group and the intervention group showed obvious pathological changes compared with that in the sham operation group.Compared with the model group，the damage degree of myocardial tissue in the intervention group was significantly reduced; compared with the sham operation group，the intima-media thickness of coronary artery in the model group and the intervention group was significantly thickened.After the intervention of Xuefu Zhuyu Decoction，the ratio of intima-media thickness of the artery in the intervention group was significantly lower than that in the model group，and the difference was statistically significant(P<005). 3)Western blotting showed：compared with the sham operation group，the expressions of PI3K and Bcl-2 in the myocardial tissue of rats in the other 2 groups underwent modeling were decreased，while the expression of Bax was increased.Xuefu Zhuyu Decoction could up-regulate the phosphorylation of PI3K and AKT，up-regulate the expression of Bcl-2，and inhibit the level of Bax.Conclusion:Xuefu Zhuyu Decoction has the effect of inhibiting vascular remodeling and protecting the heart in coronary heart disease model rats，and its mechanism may be related to mediating the PI3K-AKT signaling pathway.