| 引用本文:张雪荣1，邓丽华2，陈格格3，李云海1.“钩藤-石菖蒲”药对对TS模型大鼠神经递质及行为活动的影响[J].世界中医药,2019,(08):. |
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| “钩藤-石菖蒲”药对对TS模型大鼠神经递质及行为活动的影响 |
| Effects of Drug Pair of “Ramulus Uncariae Cum Uncis and Rhizoma Acori Tatarinowii” on Neurotransmitters and Behavioral Activities in TS Rats |
| 投稿时间：2019-04-29 |
| DOI：10.3969/j.issn.1673-7202.2019.08.020 |
| 中文关键词: “钩藤-石菖蒲”药对 TS模型大鼠 神经递质 行为活动 |
| English Keywords:Key Words drug pair of “Ramulus Uncariae Cum Uncis and Rhizoma Acori Tatarinowii” TS model rats Neurotransmitters Activities |
| 基金项目:2017年度湖北省教育厅科学研究计划指导性项目（B2017109）——“钩藤-石菖蒲”药对对抽动症大鼠神经递质影响的机制研究 |
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| 中文摘要: |
| 目的：探讨“钩藤-石菖蒲”药对对TS模型大鼠神经递质及行为活动的影响。方法：将雄性SD大鼠32只随机分为正常组、模型组、实验组、泰必利组，每组8只。造模的同时开始灌胃给药，正常组与模型组给予蒸馏水，其余各组给予相应药物，1次/d，连续给药4周。观察各组大鼠神经递质含量变化情况及各组大鼠在造模第7天及灌胃第14天、21天、28天刻板行为、运动行为、自主活动次数的情况，并分别进行评分。结果：与正常组比较，模型组多巴胺、多巴胺D2受体均无明显变化(P>005)；与模型组比较，泰必利组、实验组多巴胺、多巴胺D2受体含量均有下降(P<005)；实验组、泰必利组二组比较，差异无统计学意义(P>005)。通过对各组TS大鼠刻板行为评分比较，实验组在治疗21天以后，大鼠刻板行为减少优于泰必利组及模型组（P<005）；通过对各组TS大鼠运动行为的评分比较，泰必利组与实验组比较，差异无统计学意义(P>005)；实验组、泰必利组大鼠的活动次数较模型组均减少，二者均有治疗效果。结论：“钩藤-石菖蒲”药对具有抑制多巴胺受体超敏感、促进多巴胺代谢的作用，从而抑制TS大鼠的刻板行为，减少TS大鼠的活动次数。 |
| English Summary: |
| To investigate the effects of drug pair of “Ramulus Uncariae Cum Uncis and Rhizoma Acori Tatarinowii” on neurotransmitters and behavioral activities in TS rats.Methods:A total of 32 male SD rats were randomly divided into a normal group，a model group，an experimental group and a tabilium group，with 8 rats in each group.Intragastric administration of drugs was given when model establishing.At the same time，the normal group and the model group were given distilled water，and the other groups were given corresponding drugs，once per day，for 4 weeks.The changes of neurotransmitter content in each group of rats were observed，and the stereotyped behaviors，motor behaviors and autonomous activity times of each group of rats were evaluated on the 7th day of modeling and the 14th，21st and 28th day of instillation.Results:Compared with the normal group，there were no significant changes in dopamine and D2 receptors in the model group(P>005).Compared with the model group，the levels of dopamine and dopamine D2 receptor in the tabilium group，the experimental group all decreased(P<005).There was no significant difference between the experimental group and the tabilie group(P>005).By comparing the scores of stereotyped behaviors of TS rats in each group，after 21 days of treatment，the reduction of stereotyped behaviors of the experimental group was better than that of the tabilie group and the model group(P<005).By comparing the scores of exercise behaviors of TS rats in each group，there was no statistical significance between the tabilium group and the experimental group(P>005).The activity frequency of rats in the experimental group and the tabilium group decreased compared with the model group，and both of them had therapeutic effect.Conclusion:Drug pair of “Ramulus Uncariae Cum Uncis and Rhizoma Acori Tatarinowii” can inhibit the hypersensitivity of dopamine receptor and promote the metabolism of dopamine，thus inhibiting the stereotypical behavior of TS rats and reducing the activity frequency of TS rats. |
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