To explore the effects of Buyang Huanwu Decoction on serum phosphatidylinositol-3 kinase/serine-threonine protein kinase(PI3K/AKT)signaling pathway in patients with hypertensive intracerebral hemorrhage of qi deficiency and blood stasis type in convalescent stage，and to explore its mechanism of action in order to improve the therapeutic effect.Methods:A total of 128 patients with hypertensive intracerebral hemorrhage of qi deficiency and blood stasis type were enrolled in Sanya Traditional Chinese Medicine Hospital from January 2017 to January 2018.They were randomly divided into a control group(64 cases)and an observation group(64 cases).The control group was treated with routine western medicine and the observation group was treated with Buyang Huanwu Decoction for 4 weeks.The changes of C-reactive protein(CRP)，tumor necrosis factor-α(TNF-α)，interleukin-6(IL-6)and homocysteine(Hcy)in the 2 groups were observed and compared before and after treatment，and the changes of whole blood high-cutting viscosity，whole blood low-cutting viscosity，plasma viscosity and hematocrit in the 2 groups before and after treatment were observed and compared.The changes of PI3K，AKT，B-cell lymphoma gene-2(bcl-2)and Bcl-2 related X protein(bax)before and after treatment were observed and compared，and the changes of hemiplegia，deviation of mouth and eye，hemiplegia，shortness of breath，palpitation and sweating score before and after treatment were observed and compared between the 2 groups.Then the safety evaluation was carried out.Results: 1)There were significant differences in whole blood high-cutting viscosity，whole blood low-cutting viscosity，low shear rate，plasma viscosity and hematocrit between the 2 groups before treatment(P>005).After treatment，the above indexes of the 2 groups were significantly decreased(P<005).After treatment，the whole blood high-cutting viscosity，whole blood low-cutting viscosity，and plasma viscosity of the observation group were significantly decreased(P<005).The hematocrit was significantly lower than that of the control group(P<005). 2)The CRP，TNF-α，IL-6 and Hcy of the 2 groups before treatment were comparable(P>005).After treatment，the above indexes of the 2 groups were significantly decreased than those before treatment(P<005).After treatment，CRP，TNF-α，IL-6 and Hcy of the observation group were significantly lower than those of the control group(P<005). 3)Before treatment，PI3K，AKT，Bcl-2 and Bax in the 2 groups were comparable(P>005).After treatment，PI3K，AKT，Bcl-2 and Bax in the observation group decreased significantly compared with those before treatment(P<005)，while there was no significant difference between the control group before and after treatment(P>005).They were significantly lower than those in the control group(P<005). 4)Before treatment，there were significant differences in hemiplegia，deviation of mouth and eye，hemiparalysis，shortness of breath，fatigue，palpitation and sweating between the 2 groups(P>005).After treatment，the scores of symptoms in the 2 groups were significantly decreased than those before treatment(P<005)，and the above indexes in the observation group were significantly lower than those in the control group(P<005).Conclusion:Buyang Huanwu Decoction can down-regulate PI3K/AKT signaling pathway and inhibit inflammation，thereby inhibiting neuronal apoptosis，improving blood circulation and improving curative effect in patients with hypertensive cerebral hemorrhage of qi deficiency and blood stasis type in convalescent stage.