To explore the clinical efficacy and safety of nourishing blood and moistening meridian method in the treatment of Parkinson's disease with stiffness and hypokinesia in early and middle stages.Methods:A total of 60 cases of Parkinson's disease in the Second Affiliated Hospital of Guangzhou University of Chinese Medicine from January 2013 to February 2014 were selected as research objects.According to the random number table method，the patients were divided into control group and observation group，with 30 cases in each group.The control group was treated with Madopa，and the observation group was treated with a traditional Chinese medicine(TCM)formula adopting the method of nourishing blood and moistening tendon on the basis of Madopa.The 2 groups were treated continuously for 3 months as a course of treatment.The Unified Parkinson's Disease Quality of Life(UPDR version 30)，Hoehn-Yahr Parkinson's Disease Grading Composition Change and Parkinson's Disease Quality of Life Survey(PDQ-39)were compared between the 2 groups before and after the treatment.The total effective rate of clinical treatment was evaluated and compared between the 2 groups.Adverse drug reactions / side effects in the 2 groups were collected and compared.Results: 1)After the treatment，UPDRS scores and motor function scores in the 2 groups were significantly lower than those before the treatment，and those in the observation group were significantly lower than those in the control group(P<005). 2)After the treatment，the severity of Hoehn-Yahr in Parkinson's disease was not significantly decreased in the observation group，but it was increased in the control group.The severity of Parkinson's disease in the control group was significantly lower than that in the control group(P<005). 3)After the treatment，the scores of PDQ-39 in both groups were significantly lower than those before the treatment，and the score in the observation group was significantly lower than that in the control group(P<005). 4)After the treatment，the total effective rate of daily activities，motor function and quality of life in the observation group was significantly higher than that in the control group(P<005). 5)There was no significant difference in the incidence of adverse drug reactions between the 2 groups(P>005).Conclusion:TCM nourishing blood and moistening tendon method assisting western medicine in the treatment of Parkinson's disease with stiffness and hypokinesia in the early and middle stages can obviously improve the patients' ability of daily activity and motor function，stabilize the severity of Parkinson's disease，improve the quality of life for the patients，comprehensively improve the clinical efficacy for the patients，and do not increase the adverse drug reactions / toxic and side effects for the patients.It has high clinical value.