| 引用本文:吕少华1，2，郑春叶1，2，赖嘉华1，2，毛振辉1.养血濡筋法治疗早中期僵直少动型帕金森病患者的临床观察[J].世界中医药,2019,(08):. |
|
| 养血濡筋法治疗早中期僵直少动型帕金森病患者的临床观察 |
| Clinical Observation of Nourishing Blood and Moistening Tendon Method in the Treatment of Early and Middle-term Stiff and Hypokinetic Parkinson's Disease |
| 投稿时间：2019-01-14 |
| DOI：10.3969/j.issn.1673-7202.2019.08.028 |
| 中文关键词: 帕金森病 早中期 僵直少动型 养血濡筋法 日常活动能力 运动功能 生命质量 临床疗效 安全性 |
| English Keywords:Parkinson's disease,Early and middle stages Stiff and hypokinetic type Nourishing blood and moistening tendon method Ability of daily activities Motor function Quality of life Clinical efficacy Safety |
| 基金项目:广东省科技厅科技计划项目（2017KT1750） |
|
| 摘要点击次数: 597 |
| 全文下载次数: 611 |
| 中文摘要: |
| 目的：探讨养血濡筋法治疗早中期僵直少动型帕金森病患者的临床疗效及安全性。方法：选取2013年1月至2014年2月广州中医药大学第二附属医院收治的早中期帕金森专科患者60例作为研究对象，按照随机数字表法分为对照组和观察组，每组30例。对照组采用美多巴治疗，观察组在美多巴治疗的基础上加用中医养血濡筋法组方中药辨证分期治疗，2组患者均连续治疗3个月为1个疗程。比较2组患者治疗前后统一帕金森病生命质量和运动功能评分（UPDRS30版本）、Hoehn-Yahr帕金森病分级构成变化、帕金森病生命质量调查（PDQ-39），并对2组患者临床治疗有效率进行评估判定比较，收集2组患者治疗过程中药物不良反应并比较。结果：治疗后，2组患者UPDRS日常活动功能评分和运动功能评分均较治疗前有明显降低，且观察组明显低于对照组，差异有统计学意义（P<005)。治疗后，观察组患者Hoehn-Yahr帕金森病分级严重程度无明显降低，对照组分级严重程度升高，对照组病情严重程度分级明显低于对照组，差异有统计学意义（P<005）。治疗后2组患者PDQ-39评分均较治疗前明显下降，且观察组明显低于对照组，差异有统计学意义（P<005）。治疗后，观察组日常活动、运动功能、生命质量总有效率明显高于对照组，差异有统计学意义（P<005）；2组患者治疗过程中药物不良反应率比较，差异无统计学意义（P>005）。结论：中医养血濡筋法辅助西药治疗早中期僵直少动型帕金森患者可明显提升患者的日常活动能力、运动功能，稳定患者帕金森严重程度，提升患者生命质量，综合提高患者临床疗效，且并未增加患者药物不良反应。 |
| English Summary: |
| To explore the clinical efficacy and safety of nourishing blood and moistening meridian method in the treatment of Parkinson's disease with stiffness and hypokinesia in early and middle stages.Methods:A total of 60 cases of Parkinson's disease in the Second Affiliated Hospital of Guangzhou University of Chinese Medicine from January 2013 to February 2014 were selected as research objects.According to the random number table method，the patients were divided into control group and observation group，with 30 cases in each group.The control group was treated with Madopa，and the observation group was treated with a traditional Chinese medicine(TCM)formula adopting the method of nourishing blood and moistening tendon on the basis of Madopa.The 2 groups were treated continuously for 3 months as a course of treatment.The Unified Parkinson's Disease Quality of Life(UPDR version 30)，Hoehn-Yahr Parkinson's Disease Grading Composition Change and Parkinson's Disease Quality of Life Survey(PDQ-39)were compared between the 2 groups before and after the treatment.The total effective rate of clinical treatment was evaluated and compared between the 2 groups.Adverse drug reactions / side effects in the 2 groups were collected and compared.Results: 1)After the treatment，UPDRS scores and motor function scores in the 2 groups were significantly lower than those before the treatment，and those in the observation group were significantly lower than those in the control group(P<005). 2)After the treatment，the severity of Hoehn-Yahr in Parkinson's disease was not significantly decreased in the observation group，but it was increased in the control group.The severity of Parkinson's disease in the control group was significantly lower than that in the control group(P<005). 3)After the treatment，the scores of PDQ-39 in both groups were significantly lower than those before the treatment，and the score in the observation group was significantly lower than that in the control group(P<005). 4)After the treatment，the total effective rate of daily activities，motor function and quality of life in the observation group was significantly higher than that in the control group(P<005). 5)There was no significant difference in the incidence of adverse drug reactions between the 2 groups(P>005).Conclusion:TCM nourishing blood and moistening tendon method assisting western medicine in the treatment of Parkinson's disease with stiffness and hypokinesia in the early and middle stages can obviously improve the patients' ability of daily activity and motor function，stabilize the severity of Parkinson's disease，improve the quality of life for the patients，comprehensively improve the clinical efficacy for the patients，and do not increase the adverse drug reactions / toxic and side effects for the patients.It has high clinical value. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
