To explore the efficacy of Guben Tongluo Qufeng Formula on chronic glomerulonephritis of spleen and kidney deficiency type and its effects on the degree of renal fibrosis and systemic inflammation.Methods:A total of 108 cases of chronic glomerulonephritis with spleen and kidney deficiency were treated in our hospital during October 2015 to July 2018.They were divided into control group and observation group，with 54 cases in each group according to the random number table method.Patients in the control group were treated with routine western medicine for chronic glomerulonephritis，while those in the observation group were treated with Guben Tongluo Qufeng Formula as an adjuvant therapy.The efficacy was evaluated after 2 months of the continuous treatment.The overall efficacy，traditional Chinese medicine(TCM)syndrome score，serum renal fibrosis indicators ［cystatin C(CysC)，transforming growth factor-β1(TGF-β1)，fibronectin(FN)］ and inflammatory factors ［hs-CRP，interleukin-6(IL-6)，tumor necrosis factor-α(TNF-α)］ were compared between the 2 groups.Result：After the treatment，the effective rate of treatment in the observation group was higher than that in the control group; the scores of TCM syndromes such as fatigue，waist and knee pain，edema and poor appetite，loose stool，frequent urine and bland taste in the mouth without desire were lower than those in the control group; the levels of CysC and TGF-β1 in serum were lower than those in the control group，and the level of FN was higher than that in the control group; the levels of hs-CRP，IL-6 and TNF-α in serum were lower than those in the control group(P<005).There was no significant difference in the incidence of adverse drug reactions between the 2 groups(P>005).Conclusion:Guben Tongluo Qufeng Decoction has advantages in improving curative effect，alleviating TCM syndromes，as well as inhibiting renal fibrosis and systemic inflammatory reaction in the treatment of chronic glomerulonephritis with deficiency of spleen and kidney.