Objection:To discuss the effects on immune function in patients with advanced non-small cell lung cancer(NSCLC)using taxol and cisplatin(TP)chemotherapy combined with brucea javanica oil emulsion.Methods:A total of 108 patients with NSCLC treated from January 2017 to March 2018 in The Third Hospital of Qinhuangdao,were selected as the subjects of the study，and were randomly divided into the control group and the observation group according to the single double digital method.The control group received TP chemotherapy,and the combined group received brucea javanica oil emulsion combined with TP chemotherapy.The levels of immune cells,tumor markers,quality of life and effective rate were observed and compared between the two groups.Results:After treatment,the levels of CD3+,CD4+,CD4+/CD8+ all rose,and the levels of CD3+,CD4+,CD4+/CD8+ in the combination group were higher than those in the control group(P<005).The levels of CD8+,neuron specific enolization enzyme(NSE),sugar antigen 125(CA-125),carcinoembryonic antigen(CEA)and cytokeratin 19 fragment antigen(Cyfra21-1)all decreased,and the changes in the combination group were more obvious than those in the control group(P<005).The scores of QLQ-C30 both increased,and the score of QLQ-C30 in the combined group was higher than that in the control group,with significant difference(P<005).The effective rate in the combined group was 9444%,significantly higher than that in the control group(8149%,P<005).Conclusion:Brucea javanae oil emulsion combined with TP chemotherapy for the treatment of advanced NSCLC can effectively improve immunity,generate significant anti-tumor effect,and improve the quality of life,which is worthy for clinical application.