| 引用本文:罗丽华，宋诏民，杨建军，李鸿杰，康国权，石霞.鸦胆子油乳联合TP化疗对中晚期非小细胞肺癌患者免疫功能的影响[J].世界中医药,2019,(08):. |
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| 鸦胆子油乳联合TP化疗对中晚期非小细胞肺癌患者免疫功能的影响 |
| Effects on Immune Function in Patients with Advanced Non-small Cell Lung Cancer Using Brucea Javanica Oil Emulsion Combined with TP Chemotherapy |
| 投稿时间：2019-02-26 |
| DOI：10.3969/j.issn.1673-7202.2019.08.034 |
| 中文关键词: 非小细胞肺癌 鸦胆子油乳 紫杉醇 顺铂 T淋巴细胞 肿瘤标志物 生命质量 |
| English Keywords:Non-small cell lung cancer Brucea javanica oil emulsion Taxol Cisplatin T lymphocyte Tumor marker Quality of life |
| 基金项目:秦皇岛市科技局科学技术研究与发展计划项目(201502A091) |
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| 中文摘要: |
| 目的:探讨紫杉醇联合顺铂(TP)结合鸦胆子油乳化疗对中晚期非小细胞肺癌(NSCLC)患者免疫功能的影响。方法:选取2017年1月至2018年3月秦皇岛市第三医院收治的NSCLC患者108例作为研究对象,按照单双数字法随机分成对照组和观察组,每组54例。对照组采用TP化疗,观察组采用鸦胆子油乳联合TP化疗。观察和比较2组患者的免疫细胞、肿瘤标志物、生命质量和疗效。结果:治疗后,2组患者的CD3+、CD4+、CD4+/CD8+水平均升高,且观察组患者的CD3+、CD4+、CD4+/CD8+水平均高于对照组,差异有统计学意义(P<005);2组患者的CD8+、神经元特异性烯醇化酶(NSE)、糖类抗原-125(CA-125)、癌胚抗原(CEA)和细胞角蛋白19片段抗原(Cyfra21-1)水平均下降,且观察组患者的CD8+、NSE、CA-125、CEA和Cyfra21-1均低于对照组,差异有统计学意义(P<005);2组患者QLQ-C30评分均升高,且观察组的QLQ-C30评分高于对照组,差异有统计学意义(P<005);观察组的有效率为9444%,显著高于对照组(8149%,P<005)。结论:鸦胆子油乳联合TP化疗用于治疗中晚期NSCLC,能有效提高患者机体免疫力,发挥显著的抗肿瘤作用,并改善患者的生命质量,值得在临床上推广应用。 |
| English Summary: |
| Objection:To discuss the effects on immune function in patients with advanced non-small cell lung cancer(NSCLC)using taxol and cisplatin(TP)chemotherapy combined with brucea javanica oil emulsion.Methods:A total of 108 patients with NSCLC treated from January 2017 to March 2018 in The Third Hospital of Qinhuangdao,were selected as the subjects of the study，and were randomly divided into the control group and the observation group according to the single double digital method.The control group received TP chemotherapy,and the combined group received brucea javanica oil emulsion combined with TP chemotherapy.The levels of immune cells,tumor markers,quality of life and effective rate were observed and compared between the two groups.Results:After treatment,the levels of CD3+,CD4+,CD4+/CD8+ all rose,and the levels of CD3+,CD4+,CD4+/CD8+ in the combination group were higher than those in the control group(P<005).The levels of CD8+,neuron specific enolization enzyme(NSE),sugar antigen 125(CA-125),carcinoembryonic antigen(CEA)and cytokeratin 19 fragment antigen(Cyfra21-1)all decreased,and the changes in the combination group were more obvious than those in the control group(P<005).The scores of QLQ-C30 both increased,and the score of QLQ-C30 in the combined group was higher than that in the control group,with significant difference(P<005).The effective rate in the combined group was 9444%,significantly higher than that in the control group(8149%,P<005).Conclusion:Brucea javanae oil emulsion combined with TP chemotherapy for the treatment of advanced NSCLC can effectively improve immunity,generate significant anti-tumor effect,and improve the quality of life,which is worthy for clinical application. |
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