To explore the effects of Shenmai Injection combined with long-acting isosorbide dinitrate on platelet aggregation rate(PAR）of patients with coronary heart disease angina pectoris.Methods:A total of 87 cases patients with coronary heart disease angina pectoris admitted to Rugao People's Hospital were selected and divided randomly into a control group(n＝43）and an observation group(n＝44）according to random number table method.The control group was treated with conventional therapy+long-acting isosorbide dinitrate tablet，and the observation group was treated with Shenmai Injection.Both groups were treated continuously for 2 weeks.The clinical efficacy in the 2 groups of patients after treatment were statistically analyzed; TCM syndromes scores and total scores in the 2 groups were counted before and after treatment; The weekly angina attack times and duration in the 2 groups were observed and counted，and PAR and hemorheology indexes in the 2 groups were measured before and after treatment.Results:The total clinical efficiency in the observation group after treatment was 9545%，which was significantly higher than 6977% in the control group(P<001); compared with before treatment，the scores and total scores of chest pain，chest distress，palpitation restless，dark purple lips，darkness tongue，fine and hesitant pulse in the 2 groups were significantly reduced after treatment(P<005 or P<001)，and the observation group was significantly lower than the control group(P<001); compared with before treatment，the pain duration，times and PAR in the 2 groups were significantly shortened/reduced after treatment(P<005 or P<001)，and the observation group was significantly shorter/lower than control group(P<001); compared with before treatment，the plasma viscosity，blood sedimentation rate and high，medium and low cut viscosity after treatment in the 2 groups significantly decreased，and the observation group was significantly lower than the control group(P<005 or P<001).There was no significant difference in hematocrit of the 2 groups before and after treatment，and between the 2 groups(P>005).Conclusion:Shenmai Injection combined with long-acting isosorbide dinitrate can relieve the clinical symptoms of patients with coronary heart disease angina pectoris，reduce its PAR and blood viscosity，improve hemorheology，and the effect is significantly superior to long-acting isosorbide dinitrate treatment alone.