世界中医药
文章摘要
引用本文:姜姝1,孙淼淼2,宋魏2.参麦注射液联合长效硝酸异山梨酯对冠心病心绞痛患者血小板聚集率的影响[J].世界中医药,2019,(08):.  
参麦注射液联合长效硝酸异山梨酯对冠心病心绞痛患者血小板聚集率的影响
Effects of Shenmai Injection Combined with Long-Acting Isosorbide Dinitrate on Platelet Aggregation Rate of Patients with Coronary Heart Disease Angina Pectoris
投稿时间:2018-11-06  
DOI:10.3969/j.issn.1673-7202.2019.08.035
中文关键词:  冠心病  心绞痛  参麦注射液  长效硝酸异山梨酯  血小板聚集率  血液流变学  血浆黏度  血细胞比容  胸痛
English Keywords:Coronary heart disease  Angina pectoris  Shenmai Injection  Long-acting isosorbide dinitrate  Platelet aggregation rate  Hemorheology  Plasma viscosity  Hematocrit  Pectoralgia
基金项目:河南省医学科技攻关项目(201701029)
作者单位
姜姝1,孙淼淼2,宋魏2 1 江苏省如皋市人民医院心内科如皋226500
2 郑州大学附属肿瘤医院病理科郑州450001 
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中文摘要:
      目的:探究参麦注射液联合长效硝酸异山梨酯对冠心病心绞痛患者血小板聚集率(PAR)的影响。方法:选取2016年8月至2018年1月如皋市人民医院收治的冠心病心绞痛患者87例作为研究对象,按照随机数字表法随机分为对照组(n=43)和观察组(n=44)。对照组给予常规治疗+长效硝酸异山梨酯片治疗;观察组同时给予参麦注射液治疗,2组均连续治疗2周。治疗后统计2组患者临床疗效;统计治疗前后中医证候积分及总积分;观察并统计2组每周心绞痛发作次数及持续时间,检测2组治疗前后PAR及血液流变学指标。结果:治疗后观察组临床治疗有效率为9545%,显著高于对照组的6977%,差异有统计学意义(P<005);与治疗前比较,治疗后2组胸痛、胸闷、心悸不宁、唇色紫暗、舌暗、脉细涩积分及总积分显著降低,差异有统计学意义(P<005),且观察组显著低于对照组,差异有统计学意义(P<005);与治疗前比较,治疗后2组疼痛持续时间、次数及PAR显著缩短/降低,差异有统计学意义(P<005),且观察组显著短/低于对照组,差异有统计学意义(P<005);与治疗前比较,治疗后2组血浆黏度,红细胞沉降率及高、中、低切黏度显著降低,且观察组显著低于对照组,差异有统计学意义(P<005),2组血细胞比容治疗前后及组间差异无统计学意义(P>005)。结论:参麦注射液联合长效硝酸异山梨酯可缓解冠心病心绞痛患者临床症状,降低其PAR及血液黏稠度,改善血液流变学,效果显著优于单独长效硝酸异山梨酯治疗。
English Summary:
      To explore the effects of Shenmai Injection combined with long-acting isosorbide dinitrate on platelet aggregation rate(PAR)of patients with coronary heart disease angina pectoris.Methods:A total of 87 cases patients with coronary heart disease angina pectoris admitted to Rugao People's Hospital were selected and divided randomly into a control group(n=43)and an observation group(n=44)according to random number table method.The control group was treated with conventional therapy+long-acting isosorbide dinitrate tablet,and the observation group was treated with Shenmai Injection.Both groups were treated continuously for 2 weeks.The clinical efficacy in the 2 groups of patients after treatment were statistically analyzed; TCM syndromes scores and total scores in the 2 groups were counted before and after treatment; The weekly angina attack times and duration in the 2 groups were observed and counted,and PAR and hemorheology indexes in the 2 groups were measured before and after treatment.Results:The total clinical efficiency in the observation group after treatment was 9545%,which was significantly higher than 6977% in the control group(P<001); compared with before treatment,the scores and total scores of chest pain,chest distress,palpitation restless,dark purple lips,darkness tongue,fine and hesitant pulse in the 2 groups were significantly reduced after treatment(P<005 or P<001),and the observation group was significantly lower than the control group(P<001); compared with before treatment,the pain duration,times and PAR in the 2 groups were significantly shortened/reduced after treatment(P<005 or P<001),and the observation group was significantly shorter/lower than control group(P<001); compared with before treatment,the plasma viscosity,blood sedimentation rate and high,medium and low cut viscosity after treatment in the 2 groups significantly decreased,and the observation group was significantly lower than the control group(P<005 or P<001).There was no significant difference in hematocrit of the 2 groups before and after treatment,and between the 2 groups(P>005).Conclusion:Shenmai Injection combined with long-acting isosorbide dinitrate can relieve the clinical symptoms of patients with coronary heart disease angina pectoris,reduce its PAR and blood viscosity,improve hemorheology,and the effect is significantly superior to long-acting isosorbide dinitrate treatment alone.
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