Patients with type 2 diabetes and osteoporosis with kidney yang deficiency were treated with Jiawei Yougui Pills.To observe its clinical efficacy and to analyze its effects on the indexes of glycometabolism and bone metabolism，so as to provide a basis for diagnosis and treatment of the patients.Methods:A total of 120 patients with type 2 diabetes mellitus of kidney yang deficiency type combined with osteoporosis treated in the Chengdu 6th People's Hospital from June 2014 to July 2017 were selected as research objects，and randomly divided into control group and observation group，with 60 cases in each group.The 2 groups were treated with conventional diabetic treatment，while the control group was also treated with alfacalcidol capsules，and the observation group was treated with Jiawei Yougui Pills on the medication basis of the control group.The clinical efficacy of the 2 groups was observed，the FPG，HbA1c，GLUT4，BMD，PICP，BGP，Total-PINP and β-CTX were detected，and the results were compared and analyzed.Results:After the treatment, 1)the total effective rate of the treatment in the observation group was 9153%，and the total effective rate of the treatment in the control group was 7544%，in which the observation group was obviously superior to the control group(P<005). 2)the levels of FPG and HbA1c in the 2 groups were significantly decreased(P<005)，and the level of GLUT4 was significantly increased(P<005)，in which the observation group was superior to the control group. 3)the level of BMD，serum BGP and PICP in the 2 groups were significantly higher than those before the treatment(P<005)，while the levels of Total-PINP and β-CTX were significantly lower than those before the treatment(P<005)，in which the observation group was significantly better than the control group(P<005).Conclusion:Jiawei Yougui Pills can effectively improve the clinical efficacy in patients with type 2 diabetes of kidney yang deficiency type combined with osteoporosis，and its mechanism may be related to the improvement of glycometabolism and bone metabolism of the patients.It is worthwhile for clinical workers to use it for reference.