To observe the effects of Daming Decoction combined with donepezil on the living ability and cognitive function in patients with Alzheimer's disease(AD).Methods:A total of 60 patients with AD admitted to the Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine from January 2013 to January 2017 were enrolled in the study.They were divided into control group and observation group by the random number table,with30 cases in each group.The control group was treated with donepezil.On this basis,the observation group was treated with Daming Decoction.Each dose of the decoction was 200 mL,which was taken orally twice a day,and daily 1 agent.There were3 months in1 course of treatment,with a total of 2 courses of treatment.Scores of Mini-Mental State Examination(MMSE),Activity of Daily Living Scale(ADL),Clinical Dementia Rating(CDR）and Alzheimer's Disease Assessment Scale-Cognitive Section(ADAS-cog）in the 2 groups before the treatment,at 3 months and 6 months after the treatment were compared.Levels of serum homocysteine(Hcy),uric acid(UA),and clinical efficacy between the 2 groups before and after the treatment were compared.Results:After 3 months and 6 months of the treatment,the MMSE was significantly increased in both groups(P<005).The CDR,ADL and ADAS-cog were significantly decreased(P<005).The MMSE of the observation group was significantly higher than that of the control group at 6 months after the treatment(P<005),while the CDR,ADL and ADAS-cog were significantly lower than those of the control group(P<005).The levels of Hcy and UA in the observation group were significantly lower than those in the control group(P<005).The total effective rate of the observation group was 7714%,significantly higher than that of the control group(4857%)(χ2 = 6668,P<005).The improvement of the living ability and cognitive function of patients in the observation group was better than that in the control group.Conclusion:Daming Decoction combined with donepezil has significant efficacy in mild to moderate AD and is suitable for clinical promotion.