世界中医药
文章摘要
引用本文:文洁,陈根成.大明汤联合多奈哌齐治疗轻中度老年性痴呆患者的临床疗效[J].世界中医药,2019,(08):.  
大明汤联合多奈哌齐治疗轻中度老年性痴呆患者的临床疗效
Observation on Clinical Efficacy of Daming Decoction Combined with Donepezil in Patients with Mild to Moderate Alzheimer's Disease
投稿时间:2018-12-05  
DOI:10.3969/j.issn.1673-7202.2019.08.037
中文关键词:  老年性痴呆;中医药疗法;多奈哌齐  认知功能  生活能力
English Keywords:Alzheimer's disease  Traditional Chinese medicine therapy  Donepezil  Cognitive function  Living ability
基金项目:广东省教学基地临床改革项目(2017JD056)
作者单位
文洁,陈根成 广州中医药大学第三附属医院中西医结合脑病内科广州510360 
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中文摘要:
      目的:观察大明汤联合多奈哌齐对老年性痴呆患者(AD)生活能力和认知功能的影响。方法:选取2013年1月至2017年1月广州中医药大学第三附属医院收治的AD患者60例为研究对象,按随机数字表分为对照组和观察组,每组30例。对照组给予盐酸多奈哌齐治疗;观察组在对照组基础上给予大明汤治疗,每剂煎药200 mL,分早晚2次口服,每日1剂。3个月为1个疗程,共治疗2个疗程,比较2组患者治疗前、治疗3个月、治疗6个月的简易精神状态检查(MMSE)、日常生活自理能力量表(ADL)、痴呆程度量表(CDR)以及认知功能评定量表(ADAS-cog)评分,比较治疗前后2组患者的血清同型半胱氨酸(Hcy)、尿酸(UA)水平及临床疗效。结果:治疗3个月、治疗后6个月后;2组患者MMSE显著升高,差异有统计学意义(P<005),CDR、ADL、ADAS-cog显著降低,差异有统计学意义(P<005);观察组治疗后6个月的MMSE明显高于对照组,差异有统计学意义(P<005),CDR、ADL、ADAS-cog明显低于对照组,差异有统计学意义(P<005);观察组Hcy、UA水平显著低于对照组,差异有统计学意义(P<005);观察组总有效率为7714%,明显高于对照组的4857%,差异有统计学意义(χ2=6668,P<005),观察组患者的生活能力、认知能力改善好于对照组。结论:大明汤联合多奈哌齐对治疗轻中度AD的疗效显著。
English Summary:
      To observe the effects of Daming Decoction combined with donepezil on the living ability and cognitive function in patients with Alzheimer's disease(AD).Methods:A total of 60 patients with AD admitted to the Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine from January 2013 to January 2017 were enrolled in the study.They were divided into control group and observation group by the random number table,with30 cases in each group.The control group was treated with donepezil.On this basis,the observation group was treated with Daming Decoction.Each dose of the decoction was 200 mL,which was taken orally twice a day,and daily 1 agent.There were3 months in1 course of treatment,with a total of 2 courses of treatment.Scores of Mini-Mental State Examination(MMSE),Activity of Daily Living Scale(ADL),Clinical Dementia Rating(CDR)and Alzheimer's Disease Assessment Scale-Cognitive Section(ADAS-cog)in the 2 groups before the treatment,at 3 months and 6 months after the treatment were compared.Levels of serum homocysteine(Hcy),uric acid(UA),and clinical efficacy between the 2 groups before and after the treatment were compared.Results:After 3 months and 6 months of the treatment,the MMSE was significantly increased in both groups(P<005).The CDR,ADL and ADAS-cog were significantly decreased(P<005).The MMSE of the observation group was significantly higher than that of the control group at 6 months after the treatment(P<005),while the CDR,ADL and ADAS-cog were significantly lower than those of the control group(P<005).The levels of Hcy and UA in the observation group were significantly lower than those in the control group(P<005).The total effective rate of the observation group was 7714%,significantly higher than that of the control group(4857%)(χ2 = 6668,P<005).The improvement of the living ability and cognitive function of patients in the observation group was better than that in the control group.Conclusion:Daming Decoction combined with donepezil has significant efficacy in mild to moderate AD and is suitable for clinical promotion.
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