To investigate the therapeutic effects of Shenqi Yigan Decoction on hepatitis B fibrosis，and to analyze the changes and significance of liver function and liver fibrosis indexes before and after treatment.Methods:A total of 102 patients with hepatitis B fibrosis admitted to Rizhao Traditional Chinese Medicine Hospital from March 2014 to December 2015 were randomly divided into a control group(n=51)and an observation group(n=51).The control group was treated with routine liver-protecting drugs.The observation group was treated with Shenqi Yigan Decoction on the basis of the control group.One course was 3 months，and both groups were treated for 2 consecutive courses.The clinical efficacy，the improvement of symptoms and signs before and after treatment in the 2 groups was counted.The ultrasound imaging indicators of the 2 groups before and after the treatment were compared.The changes of serum liver function and liver fibrosis indexes before and after treatment were compared between the 2 groups.Results:After treatment，the total effective rate in the observation group was 8431%，and the total effective rate in the control group was 6863%.The total effective rate in the observation group was significantly higher than that in the control group(P<005).Compared with before treatment，the proportion of patients with symptoms and signs such as liver swelling or pain，fatigue，loss of appetite，abnormal stool and dark complexion in the 2 groups decreased significantly after treatment(P<005 or P<001)，and the proportion of patients with other symptoms and signs in the observation group was significantly lower than that in the control group(P<001).Compared with before treatment，the diameter of portal vein and spleen indices，serum ALT，AST，TBil，HA，PIII P，LN levels in the 2 groups after treatment and IV-C levels in the observation group were significantly decreased than those in the control group，and the observation group was significantly lower than those in the control group(P<005 or P<001).The right hepatic oblique diameter in the observation group was significantly reduced(P<005)，while there was no significant change in the control group(P>005).Conclusion:Shenqi Yigan Decoction can significantly improve liver function，inhibit liver fibrosis and improve clinical symptoms and signs of patients with hepatitis B fibrosis.