To compare the difference between acupoints heat-sensitive moxibustion and Seretide in treating chronic persistent asthma.Methods:A total of 30 cases of chronic persistent asthma patients in The First Affiliated Hospital of Guangzhou University of Chinese Medicine from May 2011 to November 2012 were selected and randomly divided into an observation group and a control group according to random number table，with 15 cases in each group.The observation group was given suspended moxibustion at Feishu(BL13)and Geshui(BL17)in bladder meridian of foot greater yang，with one treatment every other day，1 month as one course of treatment，for 3 courses.The control group was given seretide，one inhaled every time，twice a day，1 month as one course of treatment，for 3 courses.The pulmonary ventilation function，clinical symptoms single score and total score evaluation and clinical efficacy of the 2 groups were compared before treatment，30 days and 60 days after treatment.Results:Comparison of pulmonary ventilation function between the 2 groups：The pulmonary ventilation function(PEF，FEV1)of the 2 groups was improved after 3 months and 6 months of treatment compared with that before treatment，and there was a significant difference before and after treatment(all P<005).The improvement of the observation group was more obvious than that of the control group 3 months after treatment and 6 months after treatment(all P<005).Comparison of clinical symptom score：after 3 months and 6 months of treatment，the single symptom score and total symptom score of the 2 groups increased compared with those before treatment，with statistical significance(all P<005).The scores of clinical symptoms in the observation group were significantly higher than those in the control group after 3 months and 6 months of treatment(all P<005)，which indicated that acupoint heat-sensitive moxibustion and western medicine had improved the chronic persistence of asthma，and the observation group was better than the control group.Comparison of clinical efficacy between 2 groups：the effective rate of the observation group was 800%，and that of the control group was 533%.There was significant difference in the total effective rate between the 2 groups(P<005).Conclusion:The acupoint heat-sensitive moxibustion in the treatment of chronic persistent asthma was superior to western medicine Seretide in improving pulmonary ventilation function，clinical symptoms observation score and clinical efficacy judgment，which is worthy of clinical promotion.