| 引用本文:张玉婷，高磊，赵颖，石颖，陈宗涛.针灸联合心理干预治疗肝肾亏虚型类风湿关节炎及对患者负性情绪的影响[J].世界中医药,2019,(08):. |
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| 针灸联合心理干预治疗肝肾亏虚型类风湿关节炎及对患者负性情绪的影响 |
| Acupuncture Combined with Psychological Intervention in the Treatment of Liver and Kidney Deficiency Syndrome of Rheumatoid Arthritis and Its Effects on Patients' Negative Emotion |
| 投稿时间：2019-03-07 |
| DOI：10.3969/j.issn.1673-7202.2019.08.050 |
| 中文关键词: 类风湿关节炎 针灸 心理干预 肝肾亏虚型 炎性因子 情绪 |
| English Keywords:Rheumatoid arthritis Acupuncture Psychological intervention Deficiency of the liver and kidney Inflammatory factor Emotion |
| 基金项目:重庆市技术预见与制度创新项目（cstc2018jsyj-zdcx0023） |
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| 中文摘要: |
| 目的：探讨针灸联合心理干预治疗肝肾亏虚型类风湿关节炎及对患者负性情绪的影响。方法：选取2016年10月至2018年2月陆军军医大学第一附属医院收治的RA患者120例作为研究对象，按照随机数字表法分为对照组和观察组，每组60例。对照组给予来氟米特片和甲氨蝶呤片治疗，观察组同时联合针灸治疗，2组患者均给予心理干预，连续治疗4周。观察并记录2组患者治疗前后临床体征变化；检测血清RA相关指标及炎性因子水平；评估患者焦虑、抑郁状况改善情况。结果：治疗后2组晨僵时间较治疗前缩短，且观察组较对照组缩短更为显著（P<001）；2组压痛关节数目和肿胀关节数目较治疗前减少，且观察组少于对照组（P<001）；2组握力较治疗前明显增强，且观察组高于对照组（P<005或P<001）。治疗后2组血清RF、CCP抗体、CRP、ESR、TNF-α水平较治疗前降低，且观察组低于对照组（P<001）；2组血清TGF-β1水平较治疗前升高，且观察组高于对照组（P<001）。治疗后2组HAMA及HAMD评分均较治疗前降低，且观察组低于对照组（P<001）。结论：针灸联合心理干预治疗肝肾亏虚型类风湿关节炎可有效改善患者临床症状，降低RA相关指标及炎性因子水平，且改善了患者焦虑、抑郁等不良情绪。 |
| English Summary: |
| To explore the acupuncture combined with psychological intervention in the treatment of the liver and kidney deficiency syndrome of rheumatoid arthritis(RA)and its effects on patients' negative emotion.Methods:A total of 120 cases of RA patients treated in First Affiliated Hospital of Army Medical University from October 2016 to February 2018 were randomly divided into a control group and an observation group，with 60 cases in each group.The control group was treated with leflunomide tablets and methotrexate tablets，and the observation group was treated with acupuncture at the same time.The 2 groups were given psychological intervention for 4 weeks continuously.The clinical signs changes of the 2 groups before and after treatment were observed and recorded.The serum RA indexes and inflammatory factors levels were detected，and the improvement of anxiety and depression were evaluated.Results:The time of morning stiffness of the 2 groups after treatment were shortened compared with before treatment，and the treatment group was shorter than that of the control group(P<001).The number of pain joints and the number of swollen joints in the 2 groups were smaller than those before treatment，and the treatment group was less than the control group(P<001).The grip strength of the 2 groups was significantly higher than that before treatment，and the treatment group was higher than the control group(P<005 or P<001).After treatment，serum RF，CCP antibody，CRP，ESR and TNF-α levels in the 2 groups decreased compared with those before treatment，and the treatment group was lower than that in the control group(P<001).The serum TGF-β1 level in the 2 groups increased compared with that before treatment，and the treatment group was higher than that in the control group(P<001).After treatment，the scores of HAMA and HAMD in the 2 groups were decreased than those before treatment，and the treatment group was lower than the control group(P<001).Conclusion:Acupuncture combined with psychological intervention can effectively improve the clinical symptoms of RA patients with liver and kidney deficiency syndrome，reduce the RA indexes and the inflammatory factors levels，and improve the anxiety and depression of the patients. |
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