To explore the efficacy of ocular acupuncture combined with mecobalamin acupoint injection in traumatic oculomotor nerve palsy，in order to enrich the treatment methods and improve the efficacy.Methods:A total of 76 patients with traumatic oculomotor nerve palsy were enrolled as research objects in the Hubei Provincial Hospital of TCM from January 2017 to January 2018.They were randomly divided into control group(38 cases)and observation group(38 cases).The control group was given routine treatment，and the observation group was also given ocular acupuncture combined with mecobalamin acupoint injection for 2 weeks.Changes of diplopia score，pupil size and palpebral fissure height before and after the treatment were observed and compared between the 2 groups.Changes of nerve growth factor(NGF)，brain-derived neurotrophic factor(BDNF)and serum glial fibrillary acidic protein(GFAP)before and after the treatment were observed and compared between the 2 groups.Changes of synoptophore before and after the treatment in the 2 groups were observed and compared.Adverse reactions were evaluated in the course of the treatment and the efficacy was evaluated after the treatment.Results:There was no significant difference in the diplopia score，pupil size and palpebral fissure height between the 2 groups before the treatment(P>005).After the treatment，the diplopia score and pupil size in both groups were decreased significantly compared with those before the treatment，and the palpebral fissure height was increased significantly compared with that before the treatment(P<005).After the treatment，the diplopia score and pupil size in the observation group were significantly lower than those in the control group，and the palpebral fissure height was significantly higher than that in the control group(P<005). 2)There was no significant difference in the NGF，BDNF and GFAP between the 2 groups before the treatment(P>005).After the treatment，the NGF，BDNF and GFAP in the 2 groups were significantly higher than those before the treatment(P<005).After the treatment，the NGF，BDNF and GFAP in the observaiton group were significantly higher than those in the control group(P<005). 3)There was no significant difference in grades I，II and III of the synoptophore indexes between the 2 groups before the treatment(P>005).After the treatment，the ratios of grades I，II and III in the 2 groups were significantly higher than those before the treatment(P<005).After the treatment，the ratios of grades I，II and III in the observation group were significantly higher than those in the control group(P<005). 4)After the treatment，the marked and total effective rates in the observation group were significantly higher than those in the control group，with statisticaly significant difference(P<005). 5)There was no significant difference in safety between the 2 groups(P>005).Conclusion:Ocular acupuncture combined with acupoint injection of mecobalamin can improve the nerve conduction velocity and nerve growth factor in traumatic oculomotor nerve palsy，thereby reducing pupil size，improving diplopia symptoms and improving the efficacy.