引用本文:董兴刚,安增梅.雷公藤治疗糖尿病肾病临床应用的研究进展[J].世界中医药,2019,(08):. |
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雷公藤治疗糖尿病肾病临床应用的研究进展 |
Research Progress of Clinical Application of Radix Tripterygii Wilfordii in the Treatment of Diabetic Nephropathy |
投稿时间:2018-03-08 |
DOI:10.3969/j.issn.1673-7202.2019.08.064 |
中文关键词: 糖尿病肾病 雷公藤多苷 血管紧张素转换酶抑制剂 中药治疗 综述 蛋白尿 慢性肾脏病 随机对照 |
English Keywords:Diabetic nephropathy Tripterygium wilfordii glycosides Angiotensin converting enzyme inhibitor Treatment of Chinese materia medica Review Proteinuria Chronic kidney disease Randomized controlled |
基金项目:上海市黄浦区科委科研项目(HKM201713) |
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中文摘要: |
糖尿病已经是导致我国慢性肾脏病的第一位原因,但是迄今为止仍无治疗糖尿病肾病(Diabetic Nephropathy,DN)的有效药物,近40年来临床采用雷公藤治疗DN取得可喜成果,雷公藤多苷(Tripterygiumwilfordii Glycosides,TWG)治疗DN蛋白尿、降低尿蛋白的程度比血管紧张素转换酶抑制剂(Angiotensin Converting Enzyme Inhibitor,ACEI)更加有效,TWG亦可与ACEI联合用于DN的治疗。在一定的剂量范围内,TWG的疗效随用药剂量的增加而增强,但由于TWG的毒性问题,应注意其使用剂量、疗程。 |
English Summary: |
Diabetes mellitus is a leading cause of chronic kidney disease in China,but so far there is no effective drug for the treatment of diabetic nephropathy(DN).Nearly 40 years of clinical use of Radix Tripterygii Wilfordii in the treatment of DN has achieved gratifying results.When treating DN proteinuria with tripterygium wilfordii glycosides(TWG),its degree of reducing proteinuria is more effective than that of angiotensin converting enzyme inhibitor(ACEI).TWG can also be combined with ACEI for the treatment of DN.In a certain dose range,the therapeutic effect of TWG is enhanced with the increase of dosage.However,due to the toxicity of TWG,the dosage and course of treatment should be paid attention to. |
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